中国仓鼠卵巢细胞（CHO）Cdr变体中的细胞内金属硫蛋白浓度、锌或镉的流入速率以及金属硫蛋白mRNA积累情况
Intracellular metallothionein concentration and the rate of zinc or cadmium influx and MT mRNA accumulation in a CHO Cdr variant.
作者信息
Morris S, Huang P C
机构信息
Department of Biochemistry, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205.
出版信息
Exp Cell Res. 1989 Nov;185(1):166-75. doi: 10.1016/0014-4827(89)90046-3.
The regulation of metallothionein (MT) gene expression in a cadmium resistant CHO cell line which overproduces MT was examined in this study. Our results show that MT mRNA levels reach a maximum 24-30 h after a primary zinc exposure and, subsequently, MT mRNA concentrations decline. This decrease in MT mRNA levels can be correlated with the accumulation of metallothionein and decreased rates of zinc and cadmium uptake.
本研究检测了在过量产生金属硫蛋白（MT）的耐镉CHO细胞系中MT基因表达的调控情况。我们的结果表明，在初次锌暴露后24 - 30小时，MT mRNA水平达到最高，随后MT mRNA浓度下降。MT mRNA水平的这种下降与金属硫蛋白的积累以及锌和镉摄取速率的降低相关。
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