家庭装修与儿童白血病风险
Home remodeling and risk of childhood leukemia.
作者信息
Whitehead Todd P, Adhatamsoontra Praphopphat, Wang Yang, Arcolin Elisa, Sender Leonard, Selvin Steve, Metayer Catherine
机构信息
School of Public Health, University of California, Berkeley.
School of Public Health, University of California, Berkeley.
出版信息
Ann Epidemiol. 2017 Feb;27(2):140-144.e4. doi: 10.1016/j.annepidem.2016.11.013. Epub 2016 Dec 9.
PURPOSE
We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures.
METHODS
We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995-2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weatherproofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility.
RESULTS
Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (odds ratio [OR]: 1.52, 95% confidence interval [CI]: 1.14-2.02) and a nonsignificant increase in AML risk (OR: 1.75, 95% CI: 0.98-3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04-2.07).
CONCLUSIONS
Specific home remodeling activities appeared to be associated with increased risk of childhood ALL.
目的
我们研究了儿童白血病风险与房屋改造（作为室内化学物质暴露的替代指标）之间的关系。
方法
我们收集了参与加利福尼亚儿童白血病研究（1995 - 2008年）的609例急性淋巴细胞白血病（ALL）病例、89例急性髓细胞白血病（AML）病例和893例匹配对照家庭在孩子出生至诊断期间进行的改造活动信息。我们使用多变量逻辑回归来估计与六种改造活动相关的ALL和AML风险：建筑施工、油漆粉刷、更换地毯、更换地板、屋顶工程和防水工程。模型针对年龄、性别、西班牙裔种族、种族、家庭年收入和居住流动性进行了调整。
结果
出生至诊断期间家中进行建筑施工与ALL风险显著增加相关（优势比[OR]：1.52，95%置信区间[CI]：1.14 - 2.02），与AML风险增加但不显著相关（OR：1.75，95% CI：0.98 - 3.15）。在主要分析中，没有其他改造活动与ALL或AML风险相关。按西班牙裔种族分层时，西班牙裔儿童中ALL风险与油漆粉刷之间存在正相关关系（OR：1.47，95% CI：1.04 - 2.07）。
结论
特定的房屋改造活动似乎与儿童ALL风险增加有关。
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