Samit A M, Falk H J, Ohanian M, Leban S G, Mashberg A
J Oral Surg. 1978 Oct;36(10):816-21.
Metastatic malignant melanoma to the jaws is uncommon and is usually accompanied by generalized involvement. Hematogenous dissemination with deposition and growth in areas of hematopoietic marrow (that is, the mandibular molar region) is the accepted mechanism for involvement of the jaw. Clinical and radiographic findings are nonspecific. Comprehensive history, physical examination, and tissue microscopy are essential to accurate diagnosis and management of the patient. Radiotherapy for palliation is the accepted mode of therapy for symptomatic metastatic melanoma. Prognosis in cases with secondary jaw involvement is grave. A case of malignant melanoma with metastases to the mandible is presented and the literature is reviewed.
颌骨转移性恶性黑色素瘤并不常见，通常伴有全身受累。血行播散并在造血骨髓区域（即下颌磨牙区）沉积和生长是颌骨受累的公认机制。临床和影像学表现无特异性。全面的病史、体格检查和组织显微镜检查对于准确诊断和治疗患者至关重要。姑息性放疗是有症状的转移性黑色素瘤公认的治疗方式。继发颌骨受累病例的预后很差。本文报告一例下颌骨转移的恶性黑色素瘤病例并复习相关文献。
