Phorbol esters stimulate a phospholipase D-catalysed reaction with both ester- and ether-linked phospholipids in HeLa cells.
作者信息
Hii C S, Kokke Y S, Pruimboom W, Murray A W
机构信息
School of Biological Sciences, Flinders University, Bedford Park, South Australia.
出版信息
FEBS Lett. 1989 Oct 23;257(1):35-7. doi: 10.1016/0014-5793(89)81779-x.
PMID:2806563
Abstract
The phorbol ester, 12-tetradecanoylphorbol-13-acetate (TPA), stimulated the accumulation of labelled phosphatidylethanol (PEth) in HeLa cells prelabelled with [3H]hexadecanol and incubated in the presence of ethanol. PEth formation involves a phospholipase D-catalysed phosphatidyl transferase reaction. [3H]Hexadecanol labelled both ester- and ether-derivatives of HeLa cell phospholipids and TPA stimulated the conversion of both classes of lipid to PEth.
摘要
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