Cho Jaehyung
Department of Pharmacology, University of Illinois-Chicago College of Medicine, USA.
Pharmacol Res. 2017 Mar;117:283-287. doi: 10.1016/j.phrs.2017.01.002. Epub 2017 Jan 5.
Circulating platelets participate in the process of numerous diseases including thrombosis, inflammation, and cancer. Thus, it is of great importance to understand the underlying mechanisms mediating platelet activation under disease conditions. Emerging evidence indicates that despite the lack of a nucleus, platelets possess molecules that are involved in gene transcription in nucleated cells. This review will summarize downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, and highlight recent findings suggesting its novel non-transcriptional role in hemostasis and thrombosis.
循环血小板参与包括血栓形成、炎症和癌症在内的多种疾病的发生过程。因此，了解疾病状态下介导血小板活化的潜在机制至关重要。新出现的证据表明，尽管血小板没有细胞核，但它们拥有与有核细胞基因转录相关的分子。本综述将总结转录抑制因子下游调节元件拮抗剂调节剂（DREAM），并重点介绍其在止血和血栓形成中新型非转录作用的最新研究发现。
