Machado Ricardo Borges, Suchecki Deborah
Department of Psychology, Psychosomatic Research Group, Universidade Ibirapuera, São Paulo, Brazil; Department of Pharmacy, Psychosomatic Research Group, Universidade Ibirapuera, São Paulo, Brazil; Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil.
Front Endocrinol (Lausanne). 2016 Dec 23;7:163. doi: 10.3389/fendo.2016.00163. eCollection 2016.
Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.
睡眠稳态取决于先前清醒时间的长短和质量（例如，应激事件的发生情况）。强制清醒（睡眠剥夺或睡眠限制）是用于理解在睡眠调节的稳态过程及其相互关系中起作用的机制的主要手段之一。有趣的是，超过24小时的强制清醒会激活应激反应系统，而应激事件会影响睡眠模式。下丘脑肽（促肾上腺皮质激素释放激素、催乳素和CLIP/促肾上腺皮质激素）在应激诱导的睡眠效应的表达中起重要作用，主要是通过调节快速眼动睡眠，据称快速眼动睡眠会影响机体对应激有害影响的恢复力。本文将讨论参与睡眠产生和调节的一些机制以及参与这些反应的主要肽类/下丘脑激素。
