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乳腺癌术后放疗中,内乳淋巴结照射是否必要?

Is internal mammary nodes irradiation as a part of breast cancer postoperative radiotherapy necessary?

作者信息

Zhou Zhi-Rui, Yang Zhao-Zhi, Yu Xiao-Li, Guo Xiao-Mao

机构信息

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China;; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

J Thorac Dis. 2016 Nov;8(11):3427-3430. doi: 10.21037/jtd.2016.11.12.

DOI:10.21037/jtd.2016.11.12
PMID:28066623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179409/
Abstract

Postoperative radiotherapy plays an important role in the multidisciplinary treatment of breast cancer. However, it remains a controversy whether it is necessary to carry out prophylactic internal mammary nodes irradiation (IMNI). This review will focus on this topic. In our opinion, the total risk of relapse should be considered during the decision-making on IMNI; in particular, IMNI is recommended for high-risk patients whose tumor is located at the central/medial area or in patients with positive axillary lymph nodes.

摘要

术后放疗在乳腺癌多学科治疗中发挥着重要作用。然而,是否有必要进行预防性内乳淋巴结照射(IMNI)仍存在争议。本综述将聚焦于这一主题。我们认为,在决定是否进行IMNI时应考虑复发的总体风险;特别是,对于肿瘤位于中央/内侧区域的高危患者或腋窝淋巴结阳性的患者,建议进行IMNI。

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本文引用的文献

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Role of Internal Mammary Node Radiation as a Part of Modern Breast Cancer Radiation Therapy: A Systematic Review.内乳淋巴结放疗作为现代乳腺癌放疗一部分的作用:一项系统评价
Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):617-31. doi: 10.1016/j.ijrobp.2016.01.058. Epub 2016 Feb 12.
2
National consensus in China on diagnosis and treatment of patients with advanced breast cancer.中国晚期乳腺癌患者诊断与治疗的全国性共识。
Ann Transl Med. 2015 Oct;3(17):242. doi: 10.3978/j.issn.2305-5839.2015.09.47.
3
DBCG-IMN: A Population-Based Cohort Study on the Effect of Internal Mammary Node Irradiation in Early Node-Positive Breast Cancer.DBCG-IMN:一项基于人群的早期淋巴结阳性乳腺癌内乳淋巴结照射效果的队列研究。
J Clin Oncol. 2016 Feb 1;34(4):314-20. doi: 10.1200/JCO.2015.63.6456. Epub 2015 Nov 23.
4
Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer.乳腺癌内乳和锁骨上内侧照射。
N Engl J Med. 2015 Jul 23;373(4):317-27. doi: 10.1056/NEJMoa1415369.
5
Regional Nodal Irradiation in Early-Stage Breast Cancer.早期乳腺癌的区域淋巴结照射
N Engl J Med. 2015 Jul 23;373(4):307-16. doi: 10.1056/NEJMoa1415340.
6
Systematic review and meta-analysis comparing hypofractionated with conventional fraction radiotherapy in treatment of early breast cancer.比较早期乳腺癌治疗中,大分割放疗与传统分割放疗的系统评价和荟萃分析。
Surg Oncol. 2015 Sep;24(3):200-11. doi: 10.1016/j.suronc.2015.06.005. Epub 2015 Jun 20.
7
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Oncotarget. 2015 Jul 20;6(20):18183-91. doi: 10.18632/oncotarget.4301.
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J Thorac Dis. 2014 Jun;6(6):591-4. doi: 10.3978/j.issn.2072-1439.2014.06.21.
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