Hasaart T H, de Haan J, Horiguchi T
Department of Obstetrics and Gynecology, Academic Hospital, State University Limburg, Maastricht, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1989 Oct;33(1):39-47. doi: 10.1016/0028-2243(89)90076-2.
Total umbilical cord occlusion and selective occlusion of the umbilical arteries and veins is associated with changes in uterine blood flow. In the present study, the resistance to uterine blood flow during selective occlusions of the umbilical arteries and/or veins was analysed in five chronically instrumented pregnant sheep in the last third part of pregnancy. An occluding device which allows separate occlusion of umbilical veins and arteries was applied to the umbilical cord. Median uterine artery blood flow was measured using an electromagnetic flow meter. Maternal pressures were measured in a branch of the uterine artery and vein. Two occlusions of the umbilical veins and/or arteries with a duration of 30-60 s were performed in each animal. Selective occlusion of the umbilical arteries resulted in a small increase in uterine blood flow from 637 +/- 79 ml/min during control toward 664 +/- 77 ml/min at the end of occlusion (p less than 0.05). Uterine perfusion pressure (uterine arterial pressure - uterine venous pressure) did not change. No changes were observed in calculated uterine vascular resistance (Poiseuille equation). Selective occlusion of the umbilical veins on the other hand caused a decrease in uterine blood flow from 617 +/- 75 ml/min during control to 546 +/- 69 ml/min at the end of occlusion (p less than 0.001), and a return to control value at 1 min after occlusion. The uterine perfusion pressure increased from 40.1 +/- 6.8 mmHg during control to 42.8 +/- 7.0 mmHg at the end of occlusion (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
完全性脐带闭塞以及脐动脉和脐静脉的选择性闭塞与子宫血流变化相关。在本研究中，对五只妊娠晚期长期植入监测仪器的怀孕绵羊，分析了脐动脉和/或脐静脉选择性闭塞期间子宫血流的阻力。一种允许分别闭塞脐静脉和动脉的闭塞装置应用于脐带。使用电磁流量计测量子宫动脉血流中位数。在子宫动脉和静脉的一个分支中测量母体压力。每只动物进行两次持续30 - 60秒的脐静脉和/或动脉闭塞。脐动脉的选择性闭塞导致子宫血流略有增加，从对照期的637±79毫升/分钟增加到闭塞结束时的664±77毫升/分钟（p<0.05）。子宫灌注压（子宫动脉压 - 子宫静脉压）未改变。计算得出的子宫血管阻力（泊肃叶方程）未见变化。另一方面，脐静脉的选择性闭塞导致子宫血流从对照期的617±75毫升/分钟减少到闭塞结束时的546±69毫升/分钟（p<0.001），并在闭塞后1分钟恢复到对照值。子宫灌注压从对照期的40.1±6.8毫米汞柱增加到闭塞结束时的42.8±7.0毫米汞柱（p<0.01）。（摘要截断于250字）
