Department of Metabolism &Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Sportology Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Sci Rep. 2017 Jan 9;7:40277. doi: 10.1038/srep40277.
It has been demonstrated that moderate alcohol consumption provides protection against the development of type 2 diabetes. However, several other reports suggested that moderate alcohol intake may increase the risk of type 2 diabetes in non-obese Japanese. The aim of present study was to investigate the effect of 1-week alcohol abstinence on hepatic insulin sensitivity and fasting plasma glucose (FPG) in non-obese Japanese men. We recruited 8 non-obese Japanese men with mildly elevated FPG and drinking habits alcohol (mean frequency; 5.6 ± 2.5 times/week, mean alcohol consumption; 32.1 ± 20.0 g/day). Before and after the 1-week alcohol abstinence, we used the 2-step hyperinsulinemic-euglycemic clamp to measure endogenous glucose production (EGP) and insulin sensitivity (IS) in muscle and liver. One-week alcohol abstinence significantly reduced both FPG by 7% (from 105.5 ± 11.7 to 98.2 ± 7.8 mg/dl, P < 0.01) and fasting EGP by 6% (from 84.1 ± 4.2 to 77.6 ± 1.6 mg/m per min, P < 0.01), respectively. Two-step clamp study showed that alcohol abstinence significantly improved hepatic-IS, but not muscle-IS. In conclusion, one week alcohol abstinence improved hepatic IS and FPG in non-obese Japanese men with mildly elevated FPG and drinking habits alcohol.
已有研究表明，适量饮酒可预防 2 型糖尿病的发生。然而，其他一些研究报告表明，适量饮酒可能会增加非肥胖的日本人群患 2 型糖尿病的风险。本研究旨在探讨非肥胖的日本男性在 1 周戒酒期间，肝脏胰岛素敏感性和空腹血糖（FPG）的变化。我们招募了 8 名非肥胖、有饮酒习惯（平均频率为 5.6±2.5 次/周，平均酒精摄入量为 32.1±20.0g/天）且 FPG 轻度升高的日本男性。在 1 周戒酒前后，我们使用两步高胰岛素-正葡萄糖钳夹技术分别测量肌肉和肝脏中的内源性葡萄糖生成（EGP）和胰岛素敏感性（IS）。1 周戒酒显著降低了 FPG（从 105.5±11.7mg/dl 降至 98.2±7.8mg/dl，P<0.01）和空腹 EGP（从 84.1±4.2mg/m per min 降至 77.6±1.6mg/m per min，P<0.01），分别下降了 7%和 6%。两步钳夹试验表明，戒酒显著改善了肝脏 IS，但对肌肉 IS 没有影响。总之，1 周戒酒可改善非肥胖、有饮酒习惯且 FPG 轻度升高的日本男性的肝脏 IS 和 FPG。
