Department of Environmental and Preventive Medicine, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Innovative Clinical Research Center, Kanazawa University, Kanazawa, Japan.
J Diabetes Investig. 2021 May;12(5):869-876. doi: 10.1111/jdi.13402. Epub 2020 Oct 13.
AIMS/INTRODUCTION: A low insulin secretion capacity has been implicated in the high prevalence of non-obese diabetes in East Asians. As alcohol consumption alters insulin and glucose metabolism, we tested the hypothesis that alcohol consumption contributes to impaired insulin secretion and glucose intolerance in lean/normal-weight non-diabetic Japanese men.
This cross-sectional study was undertaken among the residents of Shika town, Japan, between 2011 and 2017. A total of 402 non-diabetic men, including participants with normal fasting plasma glucose (FPG) and impaired FPG (FPG 5.6-6.9 mmol/L), and aged ≥40 years, were examined. FPG, the homeostasis model assessment of insulin secretion capacity (HOMA-B) and alcohol consumption were evaluated and compared between the body mass index (BMI) <25 and BMI ≥25 groups.
HOMA-B levels were lower in the BMI <25 group than in the BMI ≥25 group. Alcohol consumption correlated with a low HOMA-B level regardless of BMI, and, thus, the HOMA-B levels of alcohol drinkers were significantly lower in the BMI <25 group. A multivariable logistic regression analysis showed that alcohol consumption, even light-to-moderate consumption (1-25 g/day), was associated with significantly low levels of HOMA-B and impaired FPG in the BMI <25 group. Among participants with impaired FPG, a low level of HOMA-B was observed in alcohol drinkers, but not in non-drinkers. In contrast, light-to-moderate alcohol consumption was not related to HOMA-B or FPG in the BMI ≥25-group.
Alcohol consumption, even a small amount, might contribute to reductions in HOMA-B levels and impaired FPG in lean/normal-weight Japanese men.
目的/引言：低胰岛素分泌能力与东亚地区非肥胖型糖尿病的高发有关。由于饮酒会改变胰岛素和葡萄糖代谢，我们检验了这样一个假设，即饮酒会导致瘦/正常体重的非糖尿病日本男性胰岛素分泌受损和葡萄糖耐量受损。
本横断面研究于 2011 年至 2017 年在日本志贺镇的居民中进行。共检查了 402 名非糖尿病男性，包括空腹血糖正常（FPG）和 FPG 受损（FPG 5.6-6.9mmol/L）的参与者，年龄≥40 岁。评估并比较了身体质量指数（BMI）<25 和 BMI≥25 组的 FPG、胰岛素分泌能力的稳态模型评估（HOMA-B）和酒精摄入量。
BMI<25 组的 HOMA-B 水平低于 BMI≥25 组。无论 BMI 如何，饮酒均与低 HOMA-B 水平相关，因此 BMI<25 组的饮酒者 HOMA-B 水平明显较低。多变量逻辑回归分析显示，即使是轻度至中度饮酒（1-25g/天），也与 BMI<25 组的 HOMA-B 水平显著降低和 FPG 受损相关。在 FPG 受损的参与者中，饮酒者的 HOMA-B 水平较低，但非饮酒者则不然。相比之下，轻度至中度饮酒与 BMI≥25 组的 HOMA-B 或 FPG 无关。
即使是少量饮酒，也可能导致瘦/正常体重的日本男性 HOMA-B 水平降低和 FPG 受损。
