Department of Metabolism &Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Sci Rep. 2017 Jan 9;7:39965. doi: 10.1038/srep39965.
The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study subjects, 104 patients experienced hypoglycemic episodes. Increases in the mean IMT and left maximum IMT of the common carotid arteries (CCA) were significantly greater in patients with hypoglycemia compared to those without hypoglycemia. Classification of the patients into three groups according to the frequency of hypoglycemic episodes showed that high frequency of hypoglycemic events was associated with increases in mean IMT-CCA, and left max-IMT-CCA and right max-IMT-CCA. In addition, repetitive episodes of hypoglycemia were associated with a reduction in the beneficial effects of sitagliptin on carotid IMT. Our data suggest that frequency of hypoglycemic episodes was associated with changes in carotid atherosclerosis.
低血糖对 2 型糖尿病（T2DM）患者动脉粥样硬化进展的影响在很大程度上尚不清楚。这是一项事后分析随机试验，旨在研究低血糖发作与颈动脉内膜中层厚度（IMT）变化之间的关系。在 274 名研究对象中，有 104 名患者出现低血糖发作。与无低血糖发作的患者相比，低血糖患者的颈总动脉（CCA）平均 IMT 和左侧最大 IMT 增加更明显。根据低血糖发作频率将患者分为三组，结果表明，低血糖事件的高频率与 CCA 平均 IMT、左侧最大 IMT-CCA 和右侧最大 IMT-CCA 的增加有关。此外，反复发生低血糖与西他列汀对颈动脉 IMT 的有益作用降低有关。我们的数据表明，低血糖发作的频率与颈动脉粥样硬化的变化有关。
