清醒大鼠胰多肽的释放及其在管腔反馈调节中的机制
Release of pancreatic polypeptide and its mechanism in luminal feedback regulation in the conscious rat.
作者信息
Miyasaka K, Funakoshi A, Miyazaki K, Kitani K
机构信息
First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
出版信息
Digestion. 1989;43(1-2):73-80. doi: 10.1159/000199864.
Exclusion of bile and pancreatic juice (BPJ) from the proximal intestine increases the release of pancreatic polypeptide (PP) from 4.4 to 14.3 pM and its increase was diminished by the intravenous infusion of atropine (100 micrograms/kg/h) in conscious rats. Neither intravenous bolus injection nor continuous infusion of cerulein did increase plasma PP concentration. It is suggested that the increase in plasma PP concentration produced by BPJ diversion is regulated by cholinergic mechanism, but not by cholecystokinin (CCK) released despite the known fact that BPJ diversion increases plasma CCK concentration.
将近端肠段的胆汁和胰液（BPJ）排除，可使清醒大鼠的胰多肽（PP）释放量从4.4皮摩尔升增加至14.3皮摩尔升，静脉注射阿托品（100微克/千克/小时）可减少此增加量。静脉推注或持续输注蛙皮素均未增加血浆PP浓度。提示BPJ改道引起的血浆PP浓度升高受胆碱能机制调节，而非胆囊收缩素（CCK）释放调节，尽管已知BPJ改道会增加血浆CCK浓度。
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