Castello Julia, Ragnauth Andre, Friedman Eitan, Rebholz Heike
Department of Physiology, Pharmacology and Neuroscience, City University of New York School of Medicine, New York, NY 10031, USA.
Ph.D. Programs in Biochemistry and Biology, The Graduate Center, City University of New York, New York, NY 10031, USA.
Pharmaceuticals (Basel). 2017 Jan 5;10(1):7. doi: 10.3390/ph10010007.
Protein kinase CK2 has received a surge of attention in recent years due to the evidence of its overexpression in a variety of solid tumors and multiple myelomas as well as its participation in cell survival pathways. CK2 is also upregulated in the most prevalent and aggressive cancer of brain tissue, glioblastoma multiforme, and in preclinical models, pharmacological inhibition of the kinase has proven successful in reducing tumor size and animal mortality. CK2 is highly expressed in the mammalian brain and has many bona fide substrates that are crucial in neuronal or glial homeostasis and signaling processes across synapses. Full and conditional CK2 knockout mice have further elucidated the importance of CK2 in brain development, neuronal activity, and behavior. This review will discuss recent advances in the field that point to CK2 as a regulator of neuronal functions and as a potential novel target to treat neurological and psychiatric disorders.
近年来，蛋白激酶CK2受到了广泛关注，因为有证据表明它在多种实体瘤和多发性骨髓瘤中过度表达，并且参与细胞存活途径。在最常见且侵袭性强的脑组织癌症——多形性胶质母细胞瘤中，CK2也上调，并且在临床前模型中，对该激酶的药理学抑制已证明能成功减小肿瘤大小并降低动物死亡率。CK2在哺乳动物大脑中高度表达，有许多真正的底物，这些底物在神经元或神经胶质细胞的稳态以及跨突触的信号传导过程中至关重要。完全性和条件性CK2基因敲除小鼠进一步阐明了CK2在大脑发育、神经元活动和行为中的重要性。本综述将讨论该领域的最新进展，这些进展表明CK2是神经元功能的调节因子，也是治疗神经和精神疾病的潜在新靶点。
