肝硬化腹水患者近端小管钠重吸收的锂清除率研究。

A lithium clearance study of sodium reabsorption at the proximal tubule in liver cirrhosis with ascites.

作者信息

Hattori K, Yauchi T, Minato Y, Hasumura Y, Takeuchi J, Shiigai T

机构信息

Second Department of Internal Medicine, Tokyo Medical & Dental University School of Medicine, Japan.

出版信息

Gastroenterol Jpn. 1989 Oct;24(5):535-9. doi: 10.1007/BF02773881.

DOI:10.1007/BF02773881

PMID:2806832

Abstract

Since the reabsorption of lithium occurs almost exclusively in the proximal tubule and is associated with that of sodium, the fractional excretion of lithium (FELit) ws examined in 18 patients with cirrhosis in order to examine the reabsorption rate of sodium at the proximal tubule. As expected, the fractional excretion of sodium (FENa) was significantly lower in cirrhotic patients with ascites (0.43 +/- 0.10%, mean +/- SEM) than in cirrhotic patients without ascites (0.75 +/- 0.14%, P less than 0.05) and healthy controls (0.82 +/- 0.17%, P less than 0.05). By contrast, there was no significant difference in FELit among cirrhotic patients with ascites (16.7 +/- 2.0%), cirrhotic patients without ascites (15.4 +/- 2.0%) and controls (17.4 +/- 1.5%). It is unlikely, therefore, that in cirrhotic patients with ascites, the impaired sodium excretion is solely caused by the abnormal sodium reabsorption capacity of the proximal tubule.

摘要

由于锂的重吸收几乎完全发生在近端小管，且与钠的重吸收相关，因此对18例肝硬化患者的锂排泄分数（FELit）进行了检测，以研究近端小管钠的重吸收率。正如预期的那样，有腹水的肝硬化患者的钠排泄分数（FENa）（0.43±0.10%，平均值±标准误）显著低于无腹水的肝硬化患者（0.75±0.14%，P<0.05）和健康对照者（0.82±0.17%，P<0.05）。相比之下，有腹水的肝硬化患者（16.7±2.0%）、无腹水的肝硬化患者（15.4±2.0%）和对照者（17.4±1.5%）的FELit没有显著差异。因此，有腹水的肝硬化患者钠排泄受损不太可能仅仅是由近端小管钠重吸收能力异常所致。