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CIP2A confirms its prognostic value in triple-negative breast cancer.

作者信息

Cristóbal I, Zazo S, Torrejón B, Pedregal M, Madoz-Gúrpide J, Lluch A, Eroles P, Rovira A, Albanell J, García-Foncillas J, Rojo F

机构信息

Department of Medical Oncology, Translational Oncology Division, Oncohealth Institute, Health Research Institute FJD-UAM, University Hospital 'Fundacion Jimenez Diaz', Madrid, Spain.

Department of Pathology, IIS 'Fundación Jiménez Diaz', Madrid, Spain.

出版信息

Oncogene. 2017 Jun 8;36(23):3357-3358. doi: 10.1038/onc.2016.474. Epub 2017 Jan 9.

DOI:10.1038/onc.2016.474
PMID:28068327
Abstract
摘要

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J Clin Med. 2022 Mar 14;11(6):1610. doi: 10.3390/jcm11061610.
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Expression of Phosphorylated BRD4 Is Markedly Associated with the Activation Status of the PP2A Pathway and Shows a Strong Prognostic Value in Triple Negative Breast Cancer Patients.

本文引用的文献

1
Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1.Cip2a通过调节p27Kip1的表达和核输出促进三阴性乳腺癌细胞的细胞周期进程。
Oncogene. 2017 Apr 6;36(14):1952-1964. doi: 10.1038/onc.2016.355. Epub 2016 Oct 3.
2
PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects.蛋白磷酸酶2A（PP2A）抑制决定早期乳腺癌的不良预后和阿霉素耐药性，而其激活显示出有前景的治疗效果。
Oncotarget. 2015 Feb 28;6(6):4299-314. doi: 10.18632/oncotarget.3012.
3
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.
磷酸化BRD4的表达与PP2A通路的激活状态显著相关，并在三阴性乳腺癌患者中显示出强大的预后价值。
Cancers (Basel). 2021 Mar 12;13(6):1246. doi: 10.3390/cancers13061246.
4
Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer.CIP2A 在结直肠癌恶性生物学行为中的作用及其作用机制。
Cell Commun Signal. 2020 Apr 22;18(1):67. doi: 10.1186/s12964-020-00545-6.
5
Cip2a/miR-301a feedback loop promotes cell proliferation and invasion of triple-negative breast cancer.Cip2a/miR-301a反馈环促进三阴性乳腺癌细胞的增殖和侵袭。
J Cancer. 2019 Oct 15;10(24):5964-5974. doi: 10.7150/jca.35704. eCollection 2019.
6
Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression.靶向 SET 以恢复 PP2A 活性会破坏致癌性 CIP2A 的正反馈回路，并损害三阴性乳腺癌的进展。
EBioMedicine. 2019 Feb;40:263-275. doi: 10.1016/j.ebiom.2018.12.032. Epub 2019 Jan 14.
7
Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.CIP2A 表达在实体瘤中的预后意义：一项荟萃分析。
PLoS One. 2018 Jul 25;13(7):e0199675. doi: 10.1371/journal.pone.0199675. eCollection 2018.
乳腺癌细胞衰老敏感性由 CIP2A 和 E2F1 之间的正反馈回路定义。
Cancer Discov. 2013 Feb;3(2):182-97. doi: 10.1158/2159-8290.CD-12-0292. Epub 2013 Jan 10.
4
CIP2A is associated with human breast cancer aggressivity.CIP2A与人类乳腺癌侵袭性相关。
Clin Cancer Res. 2009 Aug 15;15(16):5092-100. doi: 10.1158/1078-0432.CCR-08-3283. Epub 2009 Aug 11.