Cetin Orkun, Karaman Erbil, Boza Baris, Cim Numan, Sahin Hanım Guler
a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
J Matern Fetal Neonatal Med. 2018 Jan;31(2):216-222. doi: 10.1080/14767058.2017.1280021. Epub 2017 Jan 26.
To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor.
Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed up until delivery prospectively and the perinatal outcomes of the patients were recorded.
Of 73 women included in the study, 36 women delivered within 7 days and 37 women delivered beyond 7 days after admission. The maternal serum calponin 1 level was significantly high in women who delivered within 7 days (p: 0.031). The threshold value of 2 ng/mL for maternal serum calponin 1 predicted delivery within 7 days with 61.1% sensitivity and 62.2 specificity (area under curve, 0.658, confidence interval 0.53-0.79). The general accuracy values for maternal cervical length measurement (≤25 mm), serum calponin 1 level (>2 ng/mL) and the combination of two tests to predict delivery within 7 days was found to be 64.4%, 61.6% and 72.1%, respectively.
The maternal serum calponin 1 level may be a useful biomarker in short-term prediction of preterm birth among pregnancies complicated with threatened preterm labor, in addition to cervical length measurement.
评估孕妇血清钙调蛋白1水平在预测妊娠合并先兆早产7天内分娩中的作用。
纳入妊娠24 - 34周出现先兆早产的合格女性，采集血清钙调蛋白1水平样本并测量宫颈长度。对她们进行前瞻性随访直至分娩，并记录患者的围产期结局。
该研究纳入的73名女性中，36名女性在入院后7天内分娩，37名女性在入院7天后分娩。7天内分娩的女性血清钙调蛋白1水平显著升高（p：0.031）。孕妇血清钙调蛋白1水平阈值为2 ng/mL时，预测7天内分娩的敏感度为61.1%，特异度为62.2%（曲线下面积为0.658，置信区间为0.53 - 0.79）。发现孕妇宫颈长度测量（≤25 mm）、血清钙调蛋白1水平（>2 ng/mL）以及两项检查联合预测7天内分娩的总体准确率分别为64.4%、61.6%和72.1%。
除宫颈长度测量外，孕妇血清钙调蛋白1水平可能是妊娠合并先兆早产早产短期预测中的有用生物标志物。
