Wang Tao, Hou Jiahui, Su Chang, Zhao Liang, Shi Yijie
School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
School of Veterinary Medicine, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
J Nanobiotechnology. 2017 Jan 10;15(1):7. doi: 10.1186/s12951-016-0245-2.
A targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug-loaded NPs can be effectively delivered to selected organs and targeted cells, thus enhancing its antitumor efficiency and reducing its toxicity.
We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44.
Our new findings suggested that HA-coated chitosan NPs enhanced drug accumulation by effectively transporting NPs into CD44-overexpressed tumor cells, and they also resulted in mitochondrial damage induced by the production of reactive oxygen species (ROS). Compared to free drug and uncoated NPs, HA-coated chitosan NPs exhibited stronger inhibition rates and induced obvious apoptosis in CD44-overexpressed A549 cells.
Biocompatible and biodegradable HA-coated chitosan NPs were developed to encapsulate a chemotherapeutic drug (5-Fu) to enhance drug accumulation in tumor cells and to improve the agent's antitumor efficiency by offering targeted drug delivery via CD44.
靶向药物纳米颗粒（NP）递送系统已显示出作为一种可能的癌症治疗方法的潜力。鉴于其优点，如在肿瘤部位的选择性分布和可控的药物释放，载药纳米颗粒可以有效地递送至选定的器官和靶向细胞，从而提高其抗肿瘤效率并降低其毒性。
我们报道了透明质酸（HA）包被的壳聚糖纳米颗粒促进了5-氟尿嘧啶（5-Fu）向高表达CD44的肿瘤细胞的药物递送。
我们的新发现表明，HA包被的壳聚糖纳米颗粒通过有效地将纳米颗粒转运到CD44过表达的肿瘤细胞中增强了药物积累，并且它们还导致了由活性氧（ROS）产生引起的线粒体损伤。与游离药物和未包被的纳米颗粒相比，HA包被的壳聚糖纳米颗粒在CD44过表达的A549细胞中表现出更强的抑制率并诱导明显的细胞凋亡。
开发了生物相容性和可生物降解的HA包被的壳聚糖纳米颗粒来封装化疗药物（5-Fu），以增强药物在肿瘤细胞中的积累，并通过CD44提供靶向药物递送提高药物的抗肿瘤效率。
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