是TFIID还是非TFIID，一个持续转录的SAGA。
TFIID or not TFIID, a continuing transcriptional SAGA.
作者信息
Kubik Slawomir, Bruzzone Maria Jessica, Shore David
机构信息
Department of Molecular Biology, Institute for Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland.
出版信息
EMBO J. 2017 Feb 1;36(3):248-249. doi: 10.15252/embj.201696152. Epub 2017 Jan 9.
Abstract
Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (PIC) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge (2017) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.
摘要
真核生物蛋白质编码基因通常分为两类
一类其表达受特定信号调控，另一类是相对恒定的“管家”基因。尽管这些差异与RNA聚合酶II（RNAP II）预起始复合物（PIC）组装的不同模式相关，但基因特异性激活因子在控制“可调控性”方面的作用一直难以排除。为了解决这个问题，德容格（2017年）研究了一组受共同激活因子控制但依赖于TFIID或SAGA的基因，发现调控幅度与PIC组装机制密切相关。
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