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1
TFIID or not TFIID, a continuing transcriptional SAGA.是TFIID还是非TFIID，一个持续转录的SAGA。
EMBO J. 2017 Feb 1;36(3):248-249. doi: 10.15252/embj.201696152. Epub 2017 Jan 9.
2
SAGA mediates transcription from the TATA-like element independently of Taf1p/TFIID but dependent on core promoter structures in Saccharomyces cerevisiae.在酿酒酵母中，SAGA独立于Taf1p/TFIID，但依赖于核心启动子结构，介导从类TATA元件的转录。
PLoS One. 2017 Nov 27;12(11):e0188435. doi: 10.1371/journal.pone.0188435. eCollection 2017.
3
The Continuing SAGA of TFIID and RNA Polymerase II Transcription.TFIID 和 RNA 聚合酶 II 转录的持续传奇。
Mol Cell. 2017 Oct 5;68(1):1-2. doi: 10.1016/j.molcel.2017.09.028.
4
TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele.利用酿酒酵母taf9-ts等位基因通过全基因组合成基因阵列分析探究TFIID和Spt-Ada-Gcn5-乙酰基转移酶的功能。
Genetics. 2005 Nov;171(3):959-73. doi: 10.1534/genetics.105.046557. Epub 2005 Aug 22.
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The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.TAF9 C 端保守结构域对于 SAGA 和 TFIID 启动子占据以促进转录激活是必需的。
Mol Cell Biol. 2014 May;34(9):1547-63. doi: 10.1128/MCB.01060-13. Epub 2014 Feb 18.
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A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae.在酿酒酵母中，TFIID具有全基因组范围的管家功能，而SAGA在应激相关方面具有高度调控的功能。
Mol Cell. 2004 Feb 27;13(4):573-85. doi: 10.1016/s1097-2765(04)00087-5.
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Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.TAF6 的突变分析揭示了组蛋白折叠结构域和 HEAT 重复结构域对于转录激活的必需性。
FEBS J. 2018 Apr;285(8):1491-1510. doi: 10.1111/febs.14423. Epub 2018 Mar 23.
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Differential requirement of SAGA subunits for Mot1p and Taf1p recruitment in gene activation.基因激活过程中SAGA亚基对Mot1p和Taf1p募集的差异需求。
Mol Cell Biol. 2005 Jun;25(12):4863-72. doi: 10.1128/MCB.25.12.4863-4872.2005.
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The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription is restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains.当 Spt3，SAGA 复合物的一个亚基，通过质粒重新引入 taf1 spt3 双突变酵母菌株时，其对 PGK1 转录的功能仅部分恢复。
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Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.几乎所有酵母RNA聚合酶II转录的基因的转录都依赖于转录因子TFIID。
Mol Cell. 2017 Oct 5;68(1):118-129.e5. doi: 10.1016/j.molcel.2017.08.014. Epub 2017 Sep 14.

引用本文的文献

1
Promoter architecture determines cotranslational regulation of mRNA.启动子结构决定了 mRNA 的共翻译调控。
Genome Res. 2018 Apr;28(4):509-518. doi: 10.1101/gr.230458.117. Epub 2018 Mar 22.
2
SAGA mediates transcription from the TATA-like element independently of Taf1p/TFIID but dependent on core promoter structures in Saccharomyces cerevisiae.在酿酒酵母中，SAGA独立于Taf1p/TFIID，但依赖于核心启动子结构，介导从类TATA元件的转录。
PLoS One. 2017 Nov 27;12(11):e0188435. doi: 10.1371/journal.pone.0188435. eCollection 2017.

本文引用的文献

1
Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters.区分TFIID管家型启动子与可调节SAGA启动子的分子机制。
EMBO J. 2017 Feb 1;36(3):274-290. doi: 10.15252/embj.201695621. Epub 2016 Dec 15.
2
Affinity and competition for TBP are molecular determinants of gene expression noise.对TBP的亲和力和竞争是基因表达噪声的分子决定因素。
Nat Commun. 2016 Feb 2;7:10417. doi: 10.1038/ncomms10417.
3
Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast.核小体稳定性区分酵母所有蛋白质编码基因的两种不同启动子类型。
Mol Cell. 2015 Nov 5;60(3):422-34. doi: 10.1016/j.molcel.2015.10.002.
4
Structural basis of transcription initiation by RNA polymerase II.RNA 聚合酶 II 转录起始的结构基础。
Nat Rev Mol Cell Biol. 2015 Mar;16(3):129-43. doi: 10.1038/nrm3952. Epub 2015 Feb 18.
5
Probing the effect of promoters on noise in gene expression using thousands of designed sequences.利用数千个设计序列探究启动子对基因表达噪声的影响。
Genome Res. 2014 Oct;24(10):1698-706. doi: 10.1101/gr.168773.113. Epub 2014 Jul 16.
6
Mot1 redistributes TBP from TATA-containing to TATA-less promoters.Mot1 将 TBP 从含 TATA 盒的启动子重新分配到无 TATA 盒的启动子。
Mol Cell Biol. 2013 Dec;33(24):4996-5004. doi: 10.1128/MCB.01218-13. Epub 2013 Oct 21.
7
Structural insights into transcription initiation by RNA polymerase II.RNA 聚合酶 II 转录起始的结构见解。
Trends Biochem Sci. 2013 Dec;38(12):603-11. doi: 10.1016/j.tibs.2013.09.002. Epub 2013 Oct 11.
8
Human housekeeping genes, revisited.人类管家基因，再探。
Trends Genet. 2013 Oct;29(10):569-74. doi: 10.1016/j.tig.2013.05.010. Epub 2013 Jun 27.
9
Genome-wide structure and organization of eukaryotic pre-initiation complexes.真核生物起始前复合物的全基因组结构和组织。
Nature. 2012 Jan 18;483(7389):295-301. doi: 10.1038/nature10799.
10
One small step for Mot1; one giant leap for other Swi2/Snf2 enzymes?Mot1的一小步；其他Swi2/Snf2酶的一大步？
Biochim Biophys Acta. 2011 Sep;1809(9):488-96. doi: 10.1016/j.bbagrm.2011.05.012. Epub 2011 May 30.

是TFIID还是非TFIID，一个持续转录的SAGA。

TFIID or not TFIID, a continuing transcriptional SAGA.

作者信息

Kubik Slawomir, Bruzzone Maria Jessica, Shore David

机构信息

Department of Molecular Biology, Institute for Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland.

出版信息

EMBO J. 2017 Feb 1;36(3):248-249. doi: 10.15252/embj.201696152. Epub 2017 Jan 9.

DOI:10.15252/embj.201696152
PMID:28069707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5286358/
Abstract

Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (PIC) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge (2017) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.

摘要

真核生物蛋白质编码基因通常分为两类

一类其表达受特定信号调控，另一类是相对恒定的“管家”基因。尽管这些差异与RNA聚合酶II（RNAP II）预起始复合物（PIC）组装的不同模式相关，但基因特异性激活因子在控制“可调控性”方面的作用一直难以排除。为了解决这个问题，德容格（2017年）研究了一组受共同激活因子控制但依赖于TFIID或SAGA的基因，发现调控幅度与PIC组装机制密切相关。