调控染色质的沉默状态：拟南芥中多梳抑制复合体1的作用

Governing the Silencing State of Chromatin: The Roles of Polycomb Repressive Complex 1 in Arabidopsis.

作者信息

Yang Xianli, Tong Aizi, Yan Bowen, Wang Xiaoxue

机构信息

Rice Research Institute, Shenyang Agricultural University, Shenyang, China.

出版信息

Plant Cell Physiol. 2017 Feb 1;58(2):198-206. doi: 10.1093/pcp/pcw209.

DOI:10.1093/pcp/pcw209

PMID:28069891

Abstract

Polycomb group proteins form multiple protein complexes such as Polycomb Repressive Complex (PRC) 1 and PRC2, which repress the expression of thousands of genes. PRC1 and PRC2 are essential for normal development in Arabidopsis. Recently, significant progress has been made in understanding the functions and regulatory mechanisms of PRC1. In this review, we focus on the discovery of the composition of PRC1, functions of its components, the recruitment of PRC1 to target genes and the control of PRC1 function in Arabidopsis. Perspectives on dissecting the roles of PRC1 in plant gene expression and development are also given.

摘要

多梳蛋白家族形成多种蛋白质复合物，如多梳抑制复合物（PRC）1和PRC2，它们可抑制数千个基因的表达。PRC1和PRC2对拟南芥的正常发育至关重要。最近，在了解PRC1的功能和调控机制方面取得了重大进展。在本综述中，我们重点关注拟南芥中PRC1的组成发现、其组分的功能、PRC1募集到靶基因的过程以及PRC1功能的调控。此外，还对剖析PRC1在植物基因表达和发育中的作用提出了展望。