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Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders.

作者信息

Zarate C A, Machado-Vieira R

机构信息

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

出版信息

Mol Psychiatry. 2017 Mar;22(3):324-327. doi: 10.1038/mp.2016.249. Epub 2017 Jan 10.

DOI:10.1038/mp.2016.249
PMID:28070122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5641407/
Abstract
摘要

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Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling.氯胺酮诱导的糖原合酶激酶-3抑制作用有助于增强α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体信号传导。
Bipolar Disord. 2016 Sep;18(6):473-480. doi: 10.1111/bdi.12436. Epub 2016 Sep 30.
2
Balancing the Promise and Risks of Ketamine Treatment for Mood Disorders.平衡氯胺酮治疗情绪障碍的前景与风险
Neuropsychopharmacology. 2017 May;42(6):1179-1181. doi: 10.1038/npp.2016.193. Epub 2016 Sep 19.
3
Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression.
氯胺酮增强的延长暴露疗法治疗 PTSD 退伍军人：一项随机对照试验方案。
Contemp Clin Trials. 2024 Aug;143:107569. doi: 10.1016/j.cct.2024.107569. Epub 2024 May 9.
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Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.羟基去甲氯胺（羟考酮）而非氯胺酮通过α7 型烟碱型乙酰胆碱受体来控制突触前功能和基因表达。
Transl Psychiatry. 2024 Jan 22;14(1):47. doi: 10.1038/s41398-024-02744-y.
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Oral ketamine may offer a solution to the ketamine conundrum.口服氯胺酮可能为氯胺酮难题提供解决方案。
Psychopharmacology (Berl). 2023 Dec;240(12):2483-2497. doi: 10.1007/s00213-023-06480-x. Epub 2023 Oct 26.
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Right Frontal Theta: Is It a Response Biomarker for Ketamine's Therapeutic Action in Anxiety Disorders?右额叶θ波：它是氯胺酮治疗焦虑症的反应生物标志物吗？
Front Neurosci. 2022 Jul 4;16:900105. doi: 10.3389/fnins.2022.900105. eCollection 2022.
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Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens.氯胺酮诱导腹侧被盖区和伏隔核中 AMPA 受体钙通透性的相反变化。
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