Sparacia Gianvincenzo, Agnello Francesco, Banco Aurelia, Bencivinni Francesco, Anastasi Andrea, Giordano Giovanna, Taibbi Adele, Galia Massimo, Bartolotta Tommaso Vincenzo
Gianvincenzo Sparacia, Francesco Agnello, Aurelia Banco, Francesco Bencivinni, Andrea Anastasi, Giovanna Giordano, Adele Taibbi, Massimo Galia, Tommaso Vincenzo Bartolotta, Department of Radiology, University of Palermo, 90127 Palermo, Italy.
World J Radiol. 2016 Dec 28;8(12):916-921. doi: 10.4329/wjr.v8.i12.916.
To evaluate brain metastases volume control capabilities of stereotactic radiosurgery (SRS) through serial magnetic resonance (MR) imaging follow-up.
MR examinations of 54 brain metastases in 31 patients before and after SRS were reviewed. Patients were included in this study if they had a pre-treatment MR examination and serial follow-up MR examinations at 6 wk, 9 wk, 12 wk, and 12 mo after SRS. The metastasis volume change was categorized at each follow-up as increased (> 20% of the initial volume), stable (± 20% of the initial volume) or decreased (< 20% of the initial volume).
A local tumor control with a significant ( < 0.05) volume decrease was observed in 25 metastases at 6-wk follow-up. Not significant volume change was observed in 23 metastases and a significant volume increase was observed in 6 metastases. At 9-wk follow-up, 15 out of 25 metastases that decreased in size at 6 wk had a transient tumor volume increase, followed by tumor regression at 12 wk. At 12-wk follow-up there was a significant reduction in volume in 45 metastases, and a significant volume increase in 4 metastases. At 12-mo follow-up, 19 metastases increased significantly in size (up to 41% of the initial volume). Volume tumor reduction was correlated to histopathologic subtype.
SRS provided an effective local brain metastases volume control that was demonstrated at follow-up MR imaging.
通过系列磁共振（MR）成像随访评估立体定向放射外科（SRS）对脑转移瘤的体积控制能力。
回顾性分析31例患者54个脑转移瘤在SRS治疗前后的MR检查结果。纳入标准为：患者在SRS治疗前有MR检查，且在SRS治疗后6周、9周、12周和12个月进行了系列随访MR检查。每次随访时，将转移瘤体积变化分为增大（>初始体积的20%）、稳定（±初始体积的20%）或缩小（<初始体积的20%）。
6周随访时，25个转移瘤观察到局部肿瘤得到有效控制，体积显著减小（<0.05）。23个转移瘤体积变化不显著，6个转移瘤体积显著增大。9周随访时，6周时体积缩小的25个转移瘤中有15个出现短暂肿瘤体积增大，随后在12周时肿瘤消退。12周随访时，45个转移瘤体积显著减小，4个转移瘤体积显著增大。12个月随访时，19个转移瘤体积显著增大（增大至初始体积的41%）。肿瘤体积缩小与组织病理学亚型相关。
SRS能有效控制局部脑转移瘤体积，这在随访MR成像中得到证实。
