Fasanya Adebayo A, Loncharich Michael F, Gandhi Viral, Rana Sandeep, Balaan Marvin
Pulmonary and Critical Care Medicine, Allegheny General Hospital.
Medicine, Temple University School of Medicine.
Cureus. 2016 Nov 28;8(11):e899. doi: 10.7759/cureus.899.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease presenting with weakness and numbness in a remitting or chronic progressive course. It is known to have several clinical presentations and several associated diseases. CIDP has been associated with multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and other paraproteinemias. We present a case of refractory CIDP in which the initial workup for multiple myeloma was negative, and multiple myeloma was then diagnosed two and half years later. Treatment of the multiple myeloma led to clinical improvement. This case is instructive in that perhaps more frequent surveillance for paraproteinemia in patients with CIPD, even after a negative initial workup, could lead to a better clinical outcome.
慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）是一种自身免疫性疾病，在缓解期或慢性进展期出现肌无力和麻木症状。已知CIDP有多种临床表现及多种相关疾病。CIDP与多发性骨髓瘤、意义未明的单克隆丙种球蛋白病（MGUS）及其他副蛋白血症相关。我们报告1例难治性CIDP病例，其最初的多发性骨髓瘤检查结果为阴性，两年半后诊断为多发性骨髓瘤。多发性骨髓瘤的治疗使临床症状改善。该病例具有指导意义，即对于CIDP患者，即使初始检查结果为阴性，或许更频繁地监测副蛋白血症可带来更好的临床结局。
