应用 F18-NaF PET-CT 评估动脉粥样硬化斑块钙化。
Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT.
机构信息
ICNAS (Instituto de Ciências Nucleares Aplicadas à Saúde), Coimbra, Portugal.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
出版信息
J Nucl Cardiol. 2018 Oct;25(5):1733-1741. doi: 10.1007/s12350-016-0776-9. Epub 2017 Jan 9.
BACKGROUND
The aim of the present study was to evaluate the uptake of F18-NaF by the arterial wall in patients with high cardiovascular (CV) risk profile. The tracer uptake was assessed in relation to gender and the number of CV risk factors.
METHODS AND RESULTS
25 patients without known CV disease were included and evaluated by PET-CT with F18-NaF: 14 (56%) men and 11 (44%) women. The mean target-to-background ratio (TBR: max SUV/mean blood-pool SUV) but not the corrected uptake per lesion (CUL: max SUV - mean blood-pool SUV) was higher in men than women (TBR: 1.8 ± 0.6 vs 1.7 ± 0.2; P = 0.04; CUL: 0.7 ± 0.3 vs W 0.6 ± 0.1; P = 0.4). Patients with >3 CV risk factors had higher CUL (0.8 ± 0.1 vs 0.6 ± 0.2; P = 0.01) but not TBR (1.8 ± 0.2 vs 1.7 ± 0.6; P = 0.7) than patients with <3 risk factors.
CONCLUSIONS
The TBR but not CUL is higher in men than women while the CUL but not TBR is related to the number of CV risk factors. These results are hypothesis-generating and require validation in larger studies.
背景
本研究旨在评估高心血管（CV）风险患者的动脉壁对 F18-NaF 的摄取。通过评估性别和 CV 危险因素数量来评估示踪剂摄取。
方法和结果
共纳入 25 名无已知 CV 疾病的患者，并进行 F18-NaF PET-CT 评估：14 名（56%）男性和 11 名（44%）女性。男性的目标与背景比（TBR：最大 SUV/平均血池 SUV）但不是校正后的病变摄取（CUL：最大 SUV-平均血池 SUV）高于女性（TBR：1.8±0.6 比 1.7±0.2；P=0.04；CUL：0.7±0.3 比 0.6±0.1；P=0.4）。有>3 个 CV 危险因素的患者的 CUL 更高（0.8±0.1 比 0.6±0.2；P=0.01），但 TBR 没有差异（1.8±0.2 比 1.7±0.6；P=0.7）。
结论
男性的 TBR 高于女性，但 CUL 与 CV 危险因素的数量有关。这些结果是产生假说的，需要在更大的研究中进行验证。
Zotero 插件