Ueberschaer Hendrik, Allescher Hans-Dieter
Z Gastroenterol. 2017 Jan;55(1):63-74. doi: 10.1055/s-0042-121265. Epub 2017 Jan 10.
Proton Pump Inhibitors are among the most common drugs taken. The indication is for treatment of heartburn, reflux disease, prophylaxis and treatment of peptic ulcers, in combination with NSAIDs and steroids as well as H. pylori-eradication. PPI's are widely used, even with non-specific symptoms. This certainly has to do with good tolerability and a previously considered low side effect profile. At the moment, there is growing evidence that the long-term intake of PPI's may not be as safe as assumed. In addition to interactions with some drugs, including platelet aggregation inhibitors, recent studies have shown an increased risk of myocardial infarction, interstitial nephritis, chronic renal injury, infections, vitamin deficiencies and electrolyte shifts as well developing dementia.
质子泵抑制剂是最常用的药物之一。其适应症包括治疗烧心、反流性疾病、预防和治疗消化性溃疡，与非甾体抗炎药、类固醇联合使用以及根除幽门螺杆菌。质子泵抑制剂被广泛使用，甚至用于非特异性症状。这当然与良好的耐受性和以前认为的低副作用有关。目前，越来越多的证据表明，长期服用质子泵抑制剂可能不像人们认为的那么安全。除了与一些药物相互作用，包括血小板聚集抑制剂外，最近的研究表明，心肌梗死、间质性肾炎、慢性肾损伤、感染、维生素缺乏和电解质紊乱以及患痴呆症的风险增加。
