Department of Chemical Engineering, Delft University of Technology , Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Molecular NanoFabrication Group, MESA+ Institute for Nanotechnology, University of Twente , P.O. Box 217, 7500 AE Enschede, The Netherlands.
Nano Lett. 2017 Jan 11;17(1):1-7. doi: 10.1021/acs.nanolett.6b02360. Epub 2016 Nov 9.
Surface-modified silicon nanowire-based field-effect transistors (SiNW-FETs) have proven to be a promising platform for molecular recognition in miniature sensors. In this work, we present a novel nanoFET device for the sensitive and selective detection of explosives based on affinity layers of metal-organic polyhedra (MOPs). The judicious selection of the geometric and electronic characteristics of the assembly units (organic ligands and unsaturated metal site) embedded within the MOP cage allowed for the formation of multiple charge-transfer (CT) interactions to facilitate the selective explosive inclusion. Meanwhile, the host-stabilized CT complex inside the cage acted as an effective molecular gating element to strongly modulate the electrical conductance of the silicon nanowires. By grafting the MOP cages onto a SiNW-FET device, the resulting sensor showed a good electrical sensing capability to various explosives, especially 2,4,6-trinitrotoluene (TNT), with a detection limit below the nanomolar level. Importantly, coupling MOPs-which have tunable structures and properties-to SiNW-based devices may open up new avenues for a wide range of sensing applications, addressing various target analytes.
基于表面修饰的硅纳米线场效应晶体管（SiNW-FET）已被证明是微型传感器中分子识别的有前途的平台。在这项工作中，我们提出了一种基于金属有机多面体（MOP）亲和层的新型纳米 FET 器件，用于灵敏和选择性检测爆炸物。明智地选择组装单元（有机配体和不饱和金属位点）的几何和电子特性，这些组装单元嵌入在 MOP 笼中，允许形成多个电荷转移（CT）相互作用，以促进选择性爆炸物的包含。同时，笼内主体稳定的 CT 配合物充当有效的分子门控元件，可强烈调节硅纳米线的电导率。通过将 MOP 笼接枝到 SiNW-FET 器件上，所得传感器对各种爆炸物表现出良好的电传感能力，特别是 2,4,6-三硝基甲苯（TNT），检测限低于纳摩尔水平。重要的是，将具有可调结构和性质的 MOP 与基于 SiNW 的器件相结合，可能为广泛的传感应用开辟新途径，以应对各种目标分析物。
