Chakrabarty A N, Acharya D P, Neogi D, Dastidar S G
Indian J Med Res. 1989 Jul;89:233-7.
The antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive and Gram negative genera. The range of MIC (micrograms/ml) of Pz varied between 50 and 200 micrograms/ml among most of the test organisms. Six Pz-sensitive strains were found to be simultaneously sensitive to similar non-conventional antimicrobics, e.g., methdilazine, bromodiphenhydramine, diphenhydramine, methyl-DOPA, promazine and the antibiotic augmentin. A high degree of synergism was observed in vitro when Pz was used in combination with methdilazine and bromodiphenhydramine.
抗组胺化合物异丙嗪（Pz）在针对124株需氧菌和13株厌氧菌（属于革兰氏阳性和革兰氏阴性菌属）进行测试时，显示出显著的抗菌作用。在大多数测试微生物中，Pz的最低抑菌浓度（微克/毫升）范围在50至200微克/毫升之间。发现6株对Pz敏感的菌株同时对类似的非常规抗菌药物敏感，例如，甲哌氯丙嗪、溴苯那敏、苯海拉明、甲基多巴、丙嗪和抗生素奥格门汀。当Pz与甲哌氯丙嗪和溴苯那敏联合使用时，在体外观察到高度协同作用。
