Koike Yuya, Matsui Seishi, Omura Masao, Makita Kohzoh, Obara Alfonso W D, Moriya Nobukazu, Nishikawa Tetsuo
Department of Interventional Radiology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kouhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan.
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan.
Jpn J Radiol. 2017 Mar;35(3):126-130. doi: 10.1007/s11604-017-0612-4. Epub 2017 Jan 10.
A stress reaction involving increased adrenal hormone release occurs when starting adrenal venous sampling (AVS). The purpose of the present study was to investigate the effect of single shot venography on adrenal hormone production during AVS.
This was a prospective self-controlled study. We enrolled 54 consecutive patients (21 men, 33 women; mean age 52 ± 11 years) with primary aldosteronism who underwent AVS from May 2014 to February 2015. Under non-stimulated conditions, blood samples were obtained from a common trunk of the left adrenal vein before and after single shot venography. The initial plasma aldosterone and cortisol concentration (PAC and PCC) were compared with those measured after venography for each patient.
PAC and PCC were slightly but significantly decreased between before and after venography (after log transformation 2.12 ± 0.73 vs 2.07 ± 0.72, P = 0.00066, 1.89 ± 0.52 vs 1.83 ± 0.53, P = 0.00031, respectively).
During non-stimulated left AVS, adrenal hormone secretion was slightly but significantly decreased after venography, similar to the normal time-related stress reaction. Venography did not increase the adrenal hormone secretion.
开始肾上腺静脉采血（AVS）时会发生涉及肾上腺激素释放增加的应激反应。本研究的目的是调查单次静脉造影对AVS期间肾上腺激素产生的影响。
这是一项前瞻性自身对照研究。我们纳入了2014年5月至2015年2月期间连续接受AVS的54例原发性醛固酮增多症患者（21例男性，33例女性；平均年龄52±11岁）。在非刺激条件下，在单次静脉造影前后从左肾上腺静脉的共同主干采集血样。比较每位患者静脉造影前后测得的初始血浆醛固酮和皮质醇浓度（PAC和PCC）。
静脉造影前后PAC和PCC略有但显著降低（对数转换后分别为2.12±0.73对2.07±0.72，P = 0.00066；1.89±0.52对1.83±0.53，P = 0.00031）。
在非刺激的左侧AVS期间，静脉造影后肾上腺激素分泌略有但显著降低，类似于正常的时间相关应激反应。静脉造影未增加肾上腺激素分泌。
