Tampakis Athanasios, Tampaki Ekaterini Christina, Daikeler Thomas, Lardinois Didier
Department of General Surgery, University Hospital of Basel, Spitalstraße 2, 4056, Basel, Switzerland.
2nd Department of Propedeutic Surgery, Athens University Medical School, Laiko General Hospital, 17 Agiou Thoma Street, 11527, Athens, Greece.
Gen Thorac Cardiovasc Surg. 2017 Nov;65(11):664-666. doi: 10.1007/s11748-016-0743-z. Epub 2017 Jan 10.
Castleman's disease refers to a group of uncommon lymphoproliferative disorders which exhibit common lymph-node histological features. A 72-year-old male patient presented with signs of lower limb myositis. Detailed work-up focused initially on evaluating hematological malignancies, the presence of a solid tumor, autoimmune diseases and degenerative disorders of the peripheral nerves. Finally, a PET-CT scan was performed to exclude paraneoplastic manifestations of a primary tumor, revealing however a tumor of the thoracic wall. The definite histological diagnosis confirmed the presence of unicentric Castleman's disease of the chest wall. The manifestations of the present case suggest that a systemic inflammation might occur in the unicentric form of the disease possibly due to cytokine hypersecretion. The unicentric manifestation of the disease should be well distinguished from the multicentric appearance. Unicentric disease is a surgical condition and warrants a follow-up based on the systemic inflammation that might occur.
卡斯特曼病是指一组具有共同淋巴结组织学特征的罕见淋巴增生性疾病。一名72岁男性患者出现下肢肌炎症状。详细检查最初集中于评估血液系统恶性肿瘤、实体瘤、自身免疫性疾病和周围神经退行性疾病。最后，进行了PET-CT扫描以排除原发性肿瘤的副肿瘤表现，然而却发现了胸壁肿瘤。明确的组织学诊断证实存在胸壁单中心卡斯特曼病。本病例的表现提示，单中心型疾病可能由于细胞因子分泌过多而发生全身炎症。该疾病的单中心表现应与多中心表现进行明确区分。单中心型疾病是一种外科疾病，需要根据可能发生的全身炎症进行随访。
