Eiken Pia A, Abrahamsen Bo
Ugeskr Laeger. 2017 Jan 9;179(2).
In most patients, treatment of osteoporosis is a long-term challenge. Because alendronate and zoledronic acid accumulate in bone with some persistent antifracture efficacy after therapy, it is reasonable to consider a "drug holiday" for low-risk patients. It is recommended that the duration and length of drug holiday should be individualized for each patient. For all other bisphosphonates data are limited. For other antiresorptive and anabolic agents "drug holiday" is not recommended.
在大多数患者中，骨质疏松症的治疗是一项长期挑战。由于阿仑膦酸盐和唑来膦酸在骨中蓄积，治疗后仍具有一定的持续抗骨折疗效，因此对于低风险患者考虑“药物假期”是合理的。建议药物假期的持续时间和长度应针对每位患者个体化。对于所有其他双膦酸盐，数据有限。对于其他抗吸收和促合成药物，不建议采用“药物假期”。
