Winiarczyk Dagmara, Adaszek Łukasz, Bartnicki Michał, Abramowicz Beata, Łyp Paweł, Madany Jacek, Winiarczyk Stanisław
PhD Lukasz Adaszek, Clinic of Infectious Diseases, Faculty of Veterinary Medicine, Głęboka 30, 20-612 Lublin, Poland, Email:
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017 Apr 19;45(2):84-88. doi: 10.15654/TPK-160490. Epub 2017 Jan 11.
Canine babesiosis is a common and clinically significant tick-borne disease caused by haemoprotozoan parasites of the genus Babesia. Acute renal failure is considered to be one of the most prevalent complications of canine babesiosis. This complication leads to a decrease in the glomerular filtration rate and in consequence causes azotemia and uremia. The objective of this study was to assess the localization and extent of renal damage in dogs infected with Babesia canis using an urinary marker for glomerular (urinary immunoglobulin G, uIgG), proximal tubular dysfunction (urinary retinol binding protein, uRBP) and distal tubular dysfunction (urinary Tamm-Horsfal protein, uTHP). Material und methods: In 10 dogs naturally infected with B. canis and 10 healthy control dogs the levels of urinary biomarkers were measured using commercially available ELISA tests.
Higher concentrations of uIgG, uRBP and uTHP were found in the urine of all dogs with babesiosis than in those from the control group. This indicates that in the course of the disease, the glomeruli as well as the renal tubules become damaged.
The study results allow a better understanding of the pathogenesis of canine babesiosis. However, in order to fully determine the extent and the nature of the damage to the kidneys of the infected dogs, it is advisable to conduct additional histopathological examinations of these organs.
犬巴贝斯虫病是一种常见且具有临床意义的蜱传疾病，由巴贝斯属的血原生动物寄生虫引起。急性肾衰竭被认为是犬巴贝斯虫病最常见的并发症之一。这种并发症会导致肾小球滤过率降低，进而引起氮质血症和尿毒症。本研究的目的是使用一种用于检测肾小球（尿免疫球蛋白G，uIgG）、近端肾小管功能障碍（尿视黄醇结合蛋白，uRBP）和远端肾小管功能障碍（尿Tamm-Horsfal蛋白，uTHP）的尿液标志物，评估感染犬巴贝斯虫的犬肾脏损伤的定位和程度。材料与方法：对10只自然感染犬巴贝斯虫的犬和10只健康对照犬，使用市售ELISA检测法测量尿液生物标志物水平。
所有患巴贝斯虫病犬尿液中的uIgG、uRBP和uTHP浓度均高于对照组犬。这表明在疾病过程中，肾小球以及肾小管均受到损伤。
研究结果有助于更好地理解犬巴贝斯虫病的发病机制。然而，为了全面确定感染犬肾脏损伤的程度和性质，建议对这些器官进行额外的组织病理学检查。
