Cuevas Ada M, Lazo Mariana, Zuñiga Isabel, Carrasco Fernando, Potter Jim J, Alvarez Veronica, Berry Marcos, Maluenda Fernando, Ferrario Mario, Clark Jeanne M
1 Center of Nutrition and Metabolic Diseases , Clinica Las Condes, Santiago, Chile .
2 Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University , Baltimore, Maryland.
Metab Syndr Relat Disord. 2017 Mar;15(2):80-85. doi: 10.1089/met.2016.0104. Epub 2017 Jan 11.
The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components.
Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. Levels of inflammatory proteins, insulin resistance, cytokines, adipokines, and gene expression in subcutaneous (SAT) and visceral adipose tissue (VAT) were compared.
There was a significantly higher expression of MYD88 in SAT among those with more components of MetS (P = 0.008). In SAT, but not in VAT, MYD88 expression was significantly correlated with toll-like receptor 4 expression (r = 0.7, P < 0.05). Expression of adipsin in SAT was also associated with the presence of more components of MetS, but with borderline statistical significance (P = 0.05). There were no significant differences in insulin resistance, inflammation, and cytokine and adipokine levels by the number of components of MetS.
Our study suggests that MYD88 expression in SAT of obese subjects could be associated with the development of components of MetS.
肥胖个体发生代谢并发症的机制尚未完全明确。因此，本研究的目的是检测不同代谢综合征（MetS）组分数量的肥胖个体在胰岛素抵抗、炎症、细胞因子和脂肪因子水平以及所选基因表达方面的差异。
对40例接受减肥手术的肥胖个体进行研究，除腹部肥胖外，根据MetS组分数量分为三组（分别有0、1以及2 - 3个其他组分）。比较皮下脂肪组织（SAT）和内脏脂肪组织（VAT）中炎症蛋白、胰岛素抵抗、细胞因子、脂肪因子水平以及基因表达情况。
MetS组分较多者的SAT中MYD88表达显著更高（P = 0.008）。在SAT中而非VAT中，MYD88表达与Toll样受体4表达显著相关（r = 0.7，P < 0.05）。SAT中脂肪酶的表达也与更多MetS组分的存在相关，但具有临界统计学意义（P = 0.05）。MetS组分数量在胰岛素抵抗、炎症以及细胞因子和脂肪因子水平方面无显著差异。
我们的研究表明，肥胖受试者SAT中的MYD88表达可能与MetS组分的发生有关。
