Sheele J M, Ridge G E, Coppolino K, Bonfield T, Young A B, Gaines S L, McCormick T S
Department of Emergency Medicine, University Hospitals Cleveland Medical Center & Case Western Reserve University, Cleveland, OH, USA.
The Connecticut Agricultural Experiment Station, New Haven, CT, USA.
Parasite Immunol. 2017 Mar;39(3). doi: 10.1111/pim.12411.
Little is known about cimicosis, the resultant dermal reaction from feeding activity by the common bedbug, Cimex lectularius L. We fed C. lectularius on human study subjects four times over four weeks and measured serum cytokine and antibody levels, and subjects recorded any cimicosis. The average time for subjects to develop cimicosis decreased with each feeding from 8.4, to 2.1, 1.5 and 1.3 days, respectively. There were no significant changes in total IgG, IgG1, IgG2, IgG4 or IgE levels between the first and fourth bedbug feedings, but there was a significant decrease in total IgG3 levels (P<.001). IgG4 was not required for cimicosis. Higher IgG2 and IgG4 levels at study visit 4 were associated with an increased duration of cimicosis (P=.04) and lower pruritis (P=.03), respectively. There were no significant changes in serum TNF-α, IL-1β, IL-4, IL-5, IL-6, IL-10, IFN-γ and IL-17A levels before and one hour after the C. lectularius feeding. Lower post-C. lectularius feeding IL-6 levels were associated with increased pruritis (P=.001) and the time to maximum pruritis (P=.04), respectively. Higher post-C. lectularius feeding IL-5 levels were associated with a longer duration of pruritis (P=.05).
关于臭虫叮咬症（由常见臭虫致倦库蚊叮咬活动引起的皮肤反应），人们了解甚少。我们在四周内对人类研究对象进行了四次致倦库蚊叮咬，并测量了血清细胞因子和抗体水平，研究对象记录了任何臭虫叮咬症情况。研究对象出现臭虫叮咬症的平均时间随着每次叮咬而减少，分别从8.4天降至2.1天、1.5天和1.3天。在第一次和第四次臭虫叮咬之间，总IgG、IgG1、IgG2、IgG4或IgE水平没有显著变化，但总IgG3水平有显著下降（P<0.001）。臭虫叮咬症不需要IgG4。在第4次研究访视时，较高的IgG2和IgG4水平分别与臭虫叮咬症持续时间延长（P=0.04）和瘙痒减轻（P=0.03）相关。在致倦库蚊叮咬前和叮咬后1小时，血清TNF-α、IL-1β、IL-4、IL-5、IL-6、IL-10、IFN-γ和IL-17A水平没有显著变化。致倦库蚊叮咬后较低的IL-6水平分别与瘙痒加剧（P=0.001）和达到最大瘙痒的时间（P=0.04）相关。致倦库蚊叮咬后较高的IL-5水平与瘙痒持续时间延长（P=0.05）相关。
