Adam D, Präuer H, Sörgel F, Zürcher J
Abteilung für antimikrobielle Therapie und fektionsimmunologie, Universitäts-Kinderklinik, München.
Infection. 1989;17 Suppl 1:S21-2. doi: 10.1007/BF01643630.
For successful treatment of bacterial lung infections the administered antibiotic must reach sufficiently high concentrations in lung tissue. Therefore, the concentrations of enoxacin in this tissue were measured in ten patients requiring pulmonary surgery. In order to prevent postoperative infection, the patients received 400 mg enoxacin b.i.d. for three days. Eight h after the final dose samples of venous blood were drawn and a sample of lung tissue was removed. Using a microbiological assay, we found the following concentrations (mean +/- S.D.):serum 2.36 (+/- 0.65) mg/l, lung 6.48 (+/- 1.54) mg/kg. With the HPLC-technique the corresponding values method were 2.37 (+/- 0.80) mg/l and 7.41 (+/- 3.01) mg/kg. Thus concentrations of enoxacin in lung tissue are about three times higher than the corresponding serum concentrations.
为成功治疗细菌性肺部感染，所使用的抗生素必须在肺组织中达到足够高的浓度。因此，对10名需要进行肺部手术的患者测定了该组织中的依诺沙星浓度。为预防术后感染，患者接受400mg依诺沙星，每日两次，共三天。最后一剂给药8小时后采集静脉血样本，并取一份肺组织样本。使用微生物测定法，我们得到了以下浓度（平均值±标准差）：血清2.36（±0.65）mg/l，肺6.48（±1.54）mg/kg。采用高效液相色谱技术，相应的值分别为2.37（±0.80）mg/l和7.41（±3.01）mg/kg。因此，肺组织中依诺沙星的浓度约为相应血清浓度的三倍。
