Adam D, Weismeier K, Sörgel F, Zürcher J
Abteilung für antimikrobielle Therapie und Infektionsimmunologie, Universitäts-Kinderklinik, München.
Infection. 1989;17 Suppl 1:S25-6. doi: 10.1007/BF01643632.
For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were administered. On an average 120 (90-210) min after the final dose samples of venous blood and bone tissue were taken. The bone pieces were divided into corticalis and spongiosa. Using a bio-assay-method the following concentrations were found: (mean +/- S.D.): serum 2.88 ( +/- 0.90) mg/l, corticalis 5.90 ( +/- 0.79) mg/kg, spongiosa 3.95 ( +/- 1.01) mg/kg. Thus enoxacin reaches higher levels in bone tissue than in serum.
为成功治疗细菌性骨髓炎，所使用的抗生素必须在骨组织中达到足够高的浓度。因此，对十名需要进行髋关节手术的患者的骨组织中依诺沙星的浓度进行了测量。为预防术后感染，给予依诺沙星400毫克，每日两次，共两天。在最后一剂给药后平均120（90 - 210）分钟采集静脉血和骨组织样本。将骨块分为皮质骨和松质骨。使用生物测定法得出以下浓度：（平均值±标准差）：血清2.88（±0.90）毫克/升，皮质骨5.90（±0.79）毫克/千克，松质骨3.95（±1.01）毫克/千克。因此，依诺沙星在骨组织中的浓度高于血清中的浓度。
