Reis Luciano Dias de Oliveira, Nassif Paulo Afonso Nunes, Tabushi Fernando Issamu, Milléo Fábio Quirillo, Favero Giovani Marino, Ariede Bruno Luiz, Reis Cassiana Franco Dias Dos, Dalabona Bruno Franco
Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute, Curitiba, PR, Brazil.
Arq Bras Cir Dig. 2016 Nov-Dec;29(4):252-256. doi: 10.1590/0102-6720201600040009.
Studies related to obesity have shown association with metabolic syndrome. Data showing that obesity is capable to cause low grade chronic inflammation, without its classic signs and symptoms, call attention to researches to study different cells types and the mechanism of the inflammatory process.
To evaluate the variation of glycated hemoglobin (HbA1c) and the pro-inflammatory cytokine interleukin-6 (IL6) in diabetic patients with BMI <35 kg/m2 in the pre and postoperative of partial duodenal switch.
Nine patients were studied before and one year after the operation and the variation of the serum IL6 was measured by Elisa. The changes of HbA1c were also registered.
The pre-operative IL6 levels reached 65,50436±2,911993 pg/ml and one year after de operation 39,47739±3,410057 and the HbA1c average of 10,67 and 5.8 in the same period.
The partial duodenal switch was efficient to control one year after the procedure the chronic inflammatory process caused by the diabetes mellitus type 2 with BMI <35 by dropping the IL6 levels and bringing the HbA1c to normal.
与肥胖相关的研究表明其与代谢综合征有关。有数据显示肥胖能够引发无典型体征和症状的低度慢性炎症，这促使人们关注研究不同细胞类型及炎症过程机制的相关研究。
评估部分十二指肠转位术前后体重指数（BMI）<35kg/m²的糖尿病患者糖化血红蛋白（HbA1c）和促炎细胞因子白细胞介素-6（IL-6）的变化。
对9例患者在手术前及术后1年进行研究，采用酶联免疫吸附测定法（ELISA）检测血清IL-6的变化，并记录HbA1c的改变情况。
术前IL-6水平达到65504.36±2911.993pg/ml，术后1年为39477.39±3410.057pg/ml，同期HbA1c平均值分别为10.67和5.8。
部分十二指肠转位术在术后1年通过降低IL-6水平并使HbA1c恢复正常，有效控制了BMI<35的2型糖尿病所引发的慢性炎症过程。
