Soubihe Nathan Valle, Albuquerque Agnes Afrodite S, Arcêncio Livia, Thomazini José Antonio, Schmidt Andre, Evora Paulo Roberto B
Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Department of Internal Medicine, Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Braz J Cardiovasc Surg. 2016 Nov-Dec;31(6):465-467. doi: 10.5935/1678-9741.20160092.
Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injection, standardize the technique and attest to the safety of the method. The adaptation consists of creating myocardial microlesions that allow for better fixation of stem cells. The objective of this technical note covers only the development of the needle and the histological quality of the biopsies. It has not been used in humans yet.
经心内膜注射作为一种向患病心脏输送治疗剂的方法，其验证正在增加。穿刺心脏活检应重新成为一种可能的替代方法，以便能够进入心肌并植入用于细胞治疗的生物材料。因此，这项工作旨在展示一种用于活检和心肌内生物材料注射的经皮穿刺装置，规范该技术并证明该方法的安全性。这种改进包括制造心肌微损伤，以更好地固定干细胞。本技术说明的目标仅涵盖针的开发和活检的组织学质量。该装置尚未在人体中使用。
