Skalkidis Y, Katsouyanni K, Petridou E, Sehas M, Trichopoulos D
Department of Hygiene and Epidemiology, University of Athens Medical School, Greece.
Int J Epidemiol. 1989 Sep;18(3):614-8. doi: 10.1093/ije/18.3.614.
A case-control study concerning peripheral arterial occlusive disease (PAOD) was conducted in Athens, Greece. The case series consisted of 100 patients with PAOD as principle diagnosis admitted consecutively to a major teaching hospital in Athens during an 18-month period. The controls were patients hospitalized in the same hospital during the same period as the index cases for conditions requiring minor surgical care. All cases and controls were interviewed by the same person about several socioeconomic, demographic and medical variables; blood pressure and blood glucose values were also recorded. Data were analysed using multiple logistic regression procedures, controlling for age, sex and years of schooling. Tobacco smoking, systolic blood pressure, diabetes mellitus, heavy alcohol drinking and excessive coffee consumption were all strong independent risk factors with eight-fold or more differences in risk. It appears that PAOD as an atherosclerotic disease with low short-term fatality reveals in more contrasting terms the aetiological importance of factors involved in the atherosclerotic process as compared to atherosclerotic conditions with higher short-term fatality like coronary heart disease (CHD) which may also have stronger thrombotic components.
在希腊雅典开展了一项关于外周动脉闭塞性疾病（PAOD）的病例对照研究。病例组由100例以PAOD为主要诊断的患者组成，这些患者在18个月期间连续入住雅典一家大型教学医院。对照组为同期在同一家医院因需要小手术治疗而住院的患者。由同一人就多个社会经济、人口统计学和医学变量对所有病例和对照进行访谈；还记录了血压和血糖值。使用多元逻辑回归程序对数据进行分析，并对年龄、性别和受教育年限进行控制。吸烟、收缩压、糖尿病、大量饮酒和过量饮用咖啡均为强有力的独立危险因素，风险差异达八倍或更高。与冠心病（CHD）等短期死亡率较高且可能也有更强血栓形成成分的动脉粥样硬化疾病相比，PAOD作为一种短期死亡率较低的动脉粥样硬化疾病，似乎更鲜明地揭示了参与动脉粥样硬化过程的因素在病因学上的重要性。
