Clement P B, Young R H
Department of Pathology, Vancouver General Hospital, Canada.
Int J Gynecol Pathol. 1989;8(4):340-8. doi: 10.1097/00004347-198912000-00005.
Four cases in which nabothian cysts extended deeply into the cervical wall are described. Well differentiated adenocarcinoma of the minimal-deviation type (adenoma malignum) was an initial diagnostic consideration in three of them. The cysts were incidental findings in patients 32 to 79 years of age, who underwent hysterectomy for uterine leiomyomas (two cases), uterine prolapse (one case), and a leiomyosarcoma of the pelvic soft tissues (one case). Gross examination of the cervix in each case revealed multiple mucin-filled cysts that extended almost to the serosa or paracervical connective tissue. On microscopic examination, the cysts were characteristic of nabothian cysts, being lined by columnar to flattened endocervical-type cells devoid of atypical features or mitotic activity. Postoperative follow-up, available in three patients, was uneventful over periods of 1, 6, and 10 years. Deep nabothian cysts are an uncommon nonneoplastic lesion of the cervix that is important to distinguish from adenocarcinoma.
本文描述了4例纳博特囊肿深入宫颈壁的病例。其中3例最初考虑诊断为高分化微小偏离型腺癌（恶性腺瘤）。这些囊肿是在32至79岁的患者中偶然发现的，他们分别因子宫平滑肌瘤（2例）、子宫脱垂（1例）和盆腔软组织平滑肌肉瘤（1例）而接受子宫切除术。对每例宫颈进行大体检查，均发现多个充满黏液的囊肿，几乎延伸至浆膜或宫颈旁结缔组织。显微镜检查显示，这些囊肿具有纳博特囊肿的特征，内衬柱状至扁平的宫颈内膜型细胞，无非典型特征或有丝分裂活性。3例患者有术后随访，随访时间分别为1年、6年和10年，均无异常。深部纳博特囊肿是一种罕见的宫颈非肿瘤性病变，与腺癌进行鉴别诊断很重要。
