Nguyen Thanh D, Spincemaille Pascal, Gauthier Susan A, Wang Yi
Department of Radiology, Weill Cornell Medical College, New York, NY, United States.
Department of Radiology, Weill Cornell Medical College, New York, NY, United States.
Magn Reson Imaging. 2017 Jun;39:82-88. doi: 10.1016/j.mri.2016.12.019. Epub 2017 Jan 7.
The objective of this study is to develop rapid whole brain mapping of myelin water content (MWC) at 1.5T. The Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) pulse sequence originally developed for myelin water fraction (MWF) mapping was modified to obtain fast mapping of T1 and receiver coil sensitivity needed for MWC computation. The accuracy of the proposed T1 mapping was evaluated by comparing with the standard IR-FSE method. Numerical simulations were performed to assess the accuracy and reliability of the proposed MWC mapping. We also compared MWC values obtained with either cerebrospinal fluid (CSF) or an external water tube attached to the subject's head as the water reference. Our results from healthy volunteers show that whole brain MWC mapping is feasible in 7min and provides accurate brain T1 values. Regional brain WC and MWC measurements obtained with the internal CSF-based water standard showed excellent correlation (R>0.99) and negligible bias within narrow limits of agreement compared to those obtained with an external water standard.
本研究的目的是在1.5T条件下开发快速全脑髓鞘水含量（MWC）成像技术。最初为髓鞘水分数（MWF）成像而开发的具有螺旋轨迹和T2预脉冲的快速采集（FAST-T2）脉冲序列经过修改，以获得MWC计算所需的T1快速成像和接收线圈灵敏度。通过与标准IR-FSE方法比较，评估了所提出的T1成像的准确性。进行了数值模拟，以评估所提出的MWC成像的准确性和可靠性。我们还比较了以脑脊液（CSF）或连接到受试者头部的外部水管作为水参考所获得的MWC值。来自健康志愿者的结果表明，全脑MWC成像在7分钟内是可行的，并能提供准确的脑T1值。与使用外部水标准获得的结果相比，使用基于内部CSF的水标准获得的区域脑含水量（WC）和MWC测量结果显示出极好的相关性（R>0.99），并且在狭窄的一致性范围内偏差可忽略不计。
