Mohite Prashant N, Zeriouh Mohamed, Sáez Diana G, Popov Aron-Frederik, Sabashnikov Anton, Zych Bartlomiej, Padukone Ashok, Fazekas Levente, Ananiadou Olga, De Robertis Fabio, Soresi Simona, Reed Anna, Carby Martin, Simon André R
Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield, UK
Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield, UK.
Eur J Cardiothorac Surg. 2017 Jan;51(1):142-147. doi: 10.1093/ejcts/ezw255.
Cannabis is the most commonly abused illicit drug and the smokers are at the risk of lung infections, bullous emphysema and lung cancer. However, no evidence about the outcomes of lung transplantation (LTx) utilizing the lungs from such donors is available in the literature.
We retrospectively analysed lung 'organ offers' and LTx at our centre between January 2007 and November 2013. The outcomes of LTx utilizing lungs from donors with a history of cannabis smoking were compared with the outcomes of those with no such history using unadjusted model as well as propensity score matching.
A total of 302 LTxs were performed during this period and were grouped depending on the history of cannabis smoking in donors-'cannabis' (n = 19) and control group (n = 283). All the donors in 'cannabis' group were tobacco smokers compared with 43% in the control group. Preoperative characteristics in recipients in both groups were comparable. Intraoperative and post-LTx variables including 1- and 3-year survivals were comparable in both groups.
The history of donor cannabis smoking does not appear to affect early and mid-term outcomes after LTx and potentially improve the donor pool. As it does not seem to negatively affect the outcomes after LTx, it should not be per se considered a contraindication for lung donation.
大麻是最常被滥用的非法药物，吸食者有肺部感染、大疱性肺气肿和肺癌的风险。然而，文献中尚无关于使用此类供体的肺进行肺移植（LTx）结果的证据。
我们回顾性分析了2007年1月至2013年11月期间我们中心的肺“器官供体”和肺移植情况。使用未调整模型以及倾向评分匹配，将使用有大麻吸食史供体的肺进行肺移植的结果与无此类病史供体的肺移植结果进行比较。
在此期间共进行了302例肺移植，并根据供体的大麻吸食史分为“大麻”组（n = 19）和对照组（n = 283）。“大麻”组的所有供体均为吸烟者，而对照组为43%。两组受者的术前特征具有可比性。两组的术中及肺移植后变量，包括1年和3年生存率均具有可比性。
供体有大麻吸食史似乎并不影响肺移植后的早期和中期结果，并且可能扩大供体库。由于它似乎不会对肺移植后的结果产生负面影响，因此本身不应被视为肺捐赠的禁忌证。
