免疫球蛋白E通过增强cyp27b1表达诱导结肠癌细胞凋亡。
Immunoglobulin E induces colon cancer cell apoptosis via enhancing cyp27b1 expression.
作者信息
Ye Zhen-Shi, Fan Li-Na, Wang Lin, Yang Bin, Wang Li-Feng, Liu Yuan-Sheng, Ji Su-Na, Xu Hong-Zhi, Xiao Chuan-Xing
机构信息
Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China.
Department of Pharmacology, Medical College of Xiamen University 168 University Road, Xiamen 361005, Fujian Province, China.
出版信息
Am J Transl Res. 2016 Dec 15;8(12):5715-5722. eCollection 2016.
The pathogenesis of colon cancer (Cca) is to be further investigated. Vitamin D deficiency is associated with cancer growth; the underlying mechanism is unclear. Published data indicate that Cca cells express CD23. This study tests a hypothesis that exposure to IgE induces Cca cell apoptosis. In this study, the effect of ligation of CD23 by IgE on the expression of cyp27b1 was performed with Cca cells. The induction of apoptosis of Cca cells by IgE was assessed in a cell culture model. We observed that Cca cells express CD23; ligation of CD23 with IgE on Cca cells increased the expression of cyp27b1 in Cca, which promoted the conversion of VD3 to calcitriol, the latter increased the expression of FasL by Cca cells, and induced apoptosis of Cca cells. In conclusion, IgE is capable of inducing the cancer cell apoptosis via ligating CD23 and converting VD3 to calcitriol. The results suggest that IgE may have therapeutic potential in the treatment of Cca.
结肠癌（Cca）的发病机制有待进一步研究。维生素D缺乏与癌症生长相关；其潜在机制尚不清楚。已发表的数据表明Cca细胞表达CD23。本研究检验了一个假设，即暴露于IgE会诱导Cca细胞凋亡。在本研究中，用Cca细胞进行了IgE对CD23的结合对cyp27b1表达的影响实验。在细胞培养模型中评估了IgE对Cca细胞凋亡的诱导作用。我们观察到Cca细胞表达CD23；Cca细胞上CD23与IgE的结合增加了Cca中cyp27b1的表达，这促进了VD3向骨化三醇的转化，后者增加了Cca细胞中FasL的表达，并诱导了Cca细胞凋亡。总之，IgE能够通过结合CD23并将VD3转化为骨化三醇来诱导癌细胞凋亡。结果表明IgE在Cca治疗中可能具有治疗潜力。
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