黑色素瘤中的癌症干细胞（CSCs）：有烟雾，但真的有火吗？
Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire?
作者信息
Brinckerhoff Constance E
机构信息
Departments of Medicine and Biochemistry, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, New Hampshire.
出版信息
J Cell Physiol. 2017 Oct;232(10):2674-2678. doi: 10.1002/jcp.25796. Epub 2017 Mar 6.
Abstract
Cancer stem cells (CSCs), also called Tumor Initiating Cells (TICs), can be defined as cancer cells that are present within solid tumors or hematological cancers, which have characteristics associated with normal stem cells, but which can give rise to all cell types found in a particular cancer sample. CSCs, therefore, are transformed stem cells, which can self-renew, differentiate into diverse progenies, and drive continuous tumor growth (Kreso & Dick, , Cell Stem Cell, 14:275-291; Schatton et al., , Nature, 451:345-349; Villani, Sabbatino, Ferrone, & Ferrone, , Melanoma Management, 2:109-114; Zhou et al., , Drug Discovery, 8:806-823) (Fig. ). [Figure: see text].
摘要
癌症干细胞（CSCs），也被称为肿瘤起始细胞（TICs），可定义为存在于实体瘤或血液系统癌症中的癌细胞，它们具有与正常干细胞相关的特征，但能够产生特定癌症样本中发现的所有细胞类型。因此，癌症干细胞是转化的干细胞，能够自我更新、分化为多种子代细胞，并驱动肿瘤持续生长（克雷索和迪克，《细胞干细胞》，14:275 - 291；沙顿等人，《自然》，451:345 - 349；维拉尼、萨巴蒂诺、费罗内和费罗内，《黑色素瘤管理》，2:109 - 114；周等人，《药物发现》，8:806 - 823）（图 ）。[图：见正文]
相似文献
1
Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire?黑色素瘤中的癌症干细胞（CSCs）：有烟雾，但真的有火吗？
J Cell Physiol. 2017 Oct;232(10):2674-2678. doi: 10.1002/jcp.25796. Epub 2017 Mar 6.
2
Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics.葡萄膜黑色素瘤的表型可塑性并不局限于肿瘤亚群，且与癌症干细胞特征无关。
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5387-5395. doi: 10.1167/iovs.17-22272.
3
Existence of cancer stem cells in hepatocellular carcinoma: myth or reality?肝细胞癌中癌症干细胞的存在：是神话还是现实？
Hepatol Int. 2017 Mar;11(2):143-147. doi: 10.1007/s12072-016-9777-7. Epub 2016 Dec 18.
4
Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment.黑素瘤细胞的球体形成和自我更新能力受微环境影响。
Melanoma Res. 2012 Jun;22(3):215-24. doi: 10.1097/CMR.0b013e3283531317.
5
CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells.CXCR6，一种新定义的组织特异性干细胞不对称自我更新的生物标志物，可鉴定侵袭性更强的人类黑色素瘤癌症干细胞。
PLoS One. 2010 Dec 22;5(12):e15183. doi: 10.1371/journal.pone.0015183.
6
Learning the ABCs of melanoma-initiating cells.了解黑色素瘤起始细胞的基础知识。
Cancer Cell. 2008 Mar;13(3):185-7. doi: 10.1016/j.ccr.2008.02.015.
7
Cancer stem-like cells enriched with CD29 and CD44 markers exhibit molecular characteristics with epithelial-mesenchymal transition in squamous cell carcinoma.CD29 和 CD44 标志物富集的癌症干细胞样细胞在鳞状细胞癌中表现出具有上皮-间充质转化的分子特征。
Arch Dermatol Res. 2013 Jan;305(1):35-47. doi: 10.1007/s00403-012-1260-2. Epub 2012 Jun 28.
8
Stem cells in melanoma development.黑色素瘤发展中的干细胞。
Cancer Lett. 2009 Jul 8;279(2):119-25. doi: 10.1016/j.canlet.2008.10.039. Epub 2008 Dec 17.
9
Human breast and melanoma cancer stem cells biomarkers.人乳腺癌和黑色素瘤肿瘤干细胞标志物。
Cancer Lett. 2013 Sep 10;338(1):69-73. doi: 10.1016/j.canlet.2012.03.017. Epub 2012 Mar 20.
10
TGF-β may control the switch between tumorigenic growth and "stem cell/mesenchymal" potentially drug-resistant states.转化生长因子-β（TGF-β）可能控制着致瘤性生长与“干细胞/间充质”潜在耐药状态之间的转换。
Dermatol Ther. 2015 May-Jun;28(3):177-8. doi: 10.1111/dth.12199. Epub 2015 Feb 3.
引用本文的文献
1
Confronting Melanoma Radioresistance: Mechanisms and Therapeutic Strategies.应对黑色素瘤放射抗性：机制与治疗策略
Cancers (Basel). 2025 Aug 14;17(16):2648. doi: 10.3390/cancers17162648.
2
Supercharged Natural Killer (sNK) Cells Inhibit Melanoma Tumor Progression and Restore Endogenous NK Cell Function in Humanized BLT Mice.增强型自然杀伤（sNK）细胞抑制黑色素瘤肿瘤进展并恢复人源化BLT小鼠的内源性NK细胞功能。
Cancers (Basel). 2025 Jul 23;17(15):2430. doi: 10.3390/cancers17152430.
3
Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies.揭示黑色素瘤中癌症干细胞与肿瘤微环境之间的动态相互作用：对新型治疗策略的启示
Cancers (Basel). 2024 Aug 16;16(16):2861. doi: 10.3390/cancers16162861.
4
Correlative Raman-Electron-Light (CREL) Microscopy Analysis of Lipid Droplets in Melanoma Cancer Stem Cells.黑色素瘤肿瘤干细胞中脂滴的相关拉曼-电子-光（CREL）显微镜分析。
Biosensors (Basel). 2022 Dec 1;12(12):1102. doi: 10.3390/bios12121102.
5
YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance.YY1是黑色素瘤免疫疗法/靶向治疗耐药性中的关键因素。
Front Oncol. 2022 Jun 1;12:856963. doi: 10.3389/fonc.2022.856963. eCollection 2022.
6
NK cell upraise in the dark world of cancer stem cells.自然杀伤细胞在癌症干细胞的黑暗世界中增多。
Cancer Cell Int. 2021 Dec 19;21(1):682. doi: 10.1186/s12935-021-02400-1.
7
The Great Escape: The Power of Cancer Stem Cells to Evade Programmed Cell Death.《大逃脱：癌症干细胞逃避程序性细胞死亡的能力》
Cancers (Basel). 2021 Jan 17;13(2):328. doi: 10.3390/cancers13020328.
8
Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma.癌症干细胞与慢循环表型：如何解开黑色素瘤中驱动治疗耐药性的死结
Cancers (Basel). 2020 Nov 13;12(11):3368. doi: 10.3390/cancers12113368.
9
Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.动物癌症模型中关于永生性和自主性的证据常常未被提供，这在癌症生物学的关键问题上造成了混乱。
J Cancer. 2020 Mar 4;11(10):2887-2920. doi: 10.7150/jca.41324. eCollection 2020.
10
Expression of vimentin and Oct-4 in gallbladder adenocarcinoma and their relationship with vasculogenic mimicry and their clinical significance.波形蛋白和Oct-4在胆囊腺癌中的表达及其与血管生成拟态的关系和临床意义。
Int J Clin Exp Pathol. 2018 Jul 1;11(7):3618-3627. eCollection 2018.
本文引用的文献
1
Melanoma initiating cells: where do we stand?黑色素瘤起始细胞：我们目前的进展如何？
Melanoma Manag. 2015 May;2(2):109-114. doi: 10.2217/mmt.15.2. Epub 2015 May 18.
2
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes.用于真核基因组操作的基于CRISPR的技术
Cell. 2017 Jan 12;168(1-2):20-36. doi: 10.1016/j.cell.2016.10.044. Epub 2016 Nov 17.
3
A New Biological Feature of Natural Killer Cells: The Recognition of Solid Tumor-Derived Cancer Stem Cells.自然杀伤细胞的一种新生物学特性：对实体瘤来源的癌症干细胞的识别。
Front Immunol. 2016 May 10;7:179. doi: 10.3389/fimmu.2016.00179. eCollection 2016.
4
Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.通过造血干细胞移植产生携带人类免疫系统的免疫缺陷小鼠。
Methods Mol Biol. 2016;1438:67-78. doi: 10.1007/978-1-4939-3661-8_4.
5
Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice.破骨细胞扩增的自然杀伤细胞过继转移用于人源化小鼠中靶向癌干细胞样细胞的免疫治疗。
Cancer Immunol Immunother. 2016 Jul;65(7):835-45. doi: 10.1007/s00262-016-1822-9. Epub 2016 Mar 31.
6
Humanized hemato-lymphoid system mice.人源化血液-淋巴系统小鼠。
Haematologica. 2016 Jan;101(1):5-19. doi: 10.3324/haematol.2014.115212.
7
NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.自然杀伤细胞优先靶向具有癌症干细胞表型的肿瘤细胞。
J Immunol. 2015 Oct 15;195(8):4010-9. doi: 10.4049/jimmunol.1500447. Epub 2015 Sep 11.
8
Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations.癌症的起源细胞与癌症干细胞：检测方法与解读。
Cancer Res. 2015 Oct 1;75(19):4003-11. doi: 10.1158/0008-5472.CAN-15-0798. Epub 2015 Aug 19.
9
CD271 is an imperfect marker for melanoma initiating cells.CD271是黑色素瘤起始细胞的一个不完美标志物。
Oncotarget. 2014 Jul 30;5(14):5272-83. doi: 10.18632/oncotarget.1967.
10
Tackling the cancer stem cells - what challenges do they pose?攻克癌症干细胞——它们带来了哪些挑战？
Nat Rev Drug Discov. 2014 Jul;13(7):497-512. doi: 10.1038/nrd4253.
Zotero 插件