Ejehi Zeinab, Ariafard Alireza
Department of Chemistry, Islamic Azad University, Central Tehran Branch, Shahrak Gharb, Tehran, Iran.
Department of Chemistry, Islamic Azad University, Central Tehran Branch, Shahrak Gharb, Tehran, Iran and School of Physical Science (Chemistry), University of Tasmania, Private Bag 75, Hobart TAS 7001, Australia.
Chem Commun (Camb). 2017 Jan 24;53(8):1413-1416. doi: 10.1039/c6cc07834f.
It is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.
广泛报道称，具有两个轴向氯配体的铂（IV）前药通过氯桥连内球机制被生物还原剂还原。相比之下，在本论文中，我们证明尽管这种方法对于含硫供体的还原剂可能是正确的，但抗坏血酸盐的还原优先通过外球机制发生。
