16号染色体上的基因座与RR/Sgn近交系小鼠雌性个体中幼崽丢失倾向增加显著相关。

Locus on chromosome 16 is significantly associated with increased tendency to lose pups in females of the RR/Sgn inbred mouse strain.

作者信息

Suto Jun-Ichi

机构信息

Animal Bioregulation Unit, Institute of Agrobiological Sciences, Division of Animal Sciences, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.

出版信息

Congenit Anom (Kyoto). 2017 Mar;57(2):57-60. doi: 10.1111/cga.12199.

DOI:10.1111/cga.12199

PMID:28079294

Abstract

Females of the inbred mouse strain RR/Sgn have an apparent tendency to lose pups during rearing. To identify genes underlying this abnormal maternal phenotype, we performed quantitative trait loci (QTL) mapping in 349 (C57BL/6 J × RR/Sgn) F × RR/Sgn backcross mice and identified one significant and one suggestive QTL on chromosomes 16 and 4, respectively. We assigned the gene symbol nurturing ability QTL 3 (Naq3) to the QTL on chromosome 16. Twenty of the 21 mothers who lost entire litters were homozygous for RR/Sgn allele at Naq3; i.e., the significant association of Naq3 with pup loss was further confirmed by binomial tests. We tentatively propose that Mapk1, Kalrn, and Vps8 are potential candidate genes for Naq3.

摘要

近交系小鼠RR/Sgn的雌性在饲养过程中明显有丢失幼崽的倾向。为了确定这种异常母性行为表型背后的基因，我们在349只（C57BL/6 J×RR/Sgn）F×RR/Sgn回交小鼠中进行了数量性状基因座（QTL）定位，分别在16号和4号染色体上鉴定出一个显著QTL和一个暗示性QTL。我们将基因符号“养育能力QTL 3（Naq3）”赋予16号染色体上的QTL。在21只丢失整窝幼崽的母鼠中，有20只在Naq3位点上是RR/Sgn等位基因的纯合子；即，通过二项式检验进一步证实了Naq3与幼崽丢失之间的显著关联。我们初步提出，Mapk1、Kalrn和Vps8是Naq3的潜在候选基因。