Carpentier Claudia, Queiroz Emerson Ferreira, Marcourt Laurence, Wolfender Jean-Luc, Azelmat Jabrane, Grenier Daniel, Boudreau Stéphane, Voyer Normand
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval , 2420 Rue de la Terrasse, Québec G1V 0A6, Canada.
J Nat Prod. 2017 Jan 27;80(1):210-214. doi: 10.1021/acs.jnatprod.6b00831. Epub 2017 Jan 12.
Chemical investigation of the methanol extract of the lichen Stereocaulon paschale collected in Nunavik, Canada, led to the isolation and identification of two new dibenzofurans (1 and 3) and 11 known lichen metabolites. The structures of the new compounds were established by analysis of 1D and 2D NMR spectroscopic and high-resolution mass spectrometric data. Herein, the first isolation of ascomatic acid dibenzofuran derivatives (1-3) from a whole lichen organism is reported. In addition, some of the isolated metabolites showed antibacterial activity against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans.
对采集于加拿大努纳维克的地衣Stereocaulon paschale甲醇提取物进行化学研究，分离并鉴定出两种新的二苯并呋喃（1和3）以及11种已知的地衣代谢物。通过一维和二维核磁共振光谱分析以及高分辨率质谱数据确定了新化合物的结构。本文报道了首次从完整的地衣生物体中分离出子囊酸二苯并呋喃衍生物（1 - 3）。此外，一些分离出的代谢物对口腔病原体牙龈卟啉单胞菌和变形链球菌具有抗菌活性。
