神经内分泌细胞的转分化：与多发性内分泌腺瘤1型中不同谱系的两个垂体腺瘤相关的神经节细胞瘤。

Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.

作者信息

Sergeant Camille, Jublanc Christel, Leclercq Delphine, Boch Anne-Laure, Bielle Franck, Raverot Gerald, Daly Adrian F, Trouillas Jacqueline, Villa Chiara

机构信息

Departments of *Endocrinology †Radiology ‡Neurosurgery, Pitié Salpêtrière-Charles Foix Hospital §Department of Neuropathology Raymond-Escourolle, Pitié Salpêtrière-Charles Foix Hospital, INSERM U1127, CNRS UMR 7225, UPMC-Sorbonne University, Brain and Spine Institute ††INSERM U1016, CNRS UMR8104, Paris Descartes University, Cochin Institute, Paris ∥Endocrinology Federation, GH East, Civil Hospital of Lyon, Bron Cedex ¶INSERM U1028, CNRS UMR5292, Lyon 1 University, Neuroscience Center, Lyon **Department of Pathological Cytology and Anatomy, Foch Hospital, Suresnes, France #Department of Endocrinology, CHU de Liège, University of Liège, Liège, Belgium.

出版信息

Am J Surg Pathol. 2017 Jun;41(6):849-853. doi: 10.1097/PAS.0000000000000803.

DOI:10.1097/PAS.0000000000000803

PMID:28079577

Abstract

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed.

摘要

神经节细胞瘤是一种罕见的良性神经元细胞肿瘤，多见于下丘脑和鞍区。其组织发生仍是讨论的主题。在此，我们报告一例患有多发性内分泌腺瘤1型（MEN1）的患者，其垂体神经节细胞瘤与泌乳素瘤和促肾上腺皮质激素腺瘤相关。组织学研究揭示了腺瘤细胞和神经元细胞之间的共同特征，支持了共同起源或转分化现象的病因学假说。此外，神经节细胞瘤可能是一种与MEN1相关的新肿瘤。本文讨论了临床和组织学观察结果，并对该主题的文献进行了综述。