Bunting Bryant, Knight Joshua, McHugh Stephen M
From the Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
A A Case Rep. 2017 Mar 1;8(5):116-118. doi: 10.1213/XAA.0000000000000442.
Malignant Hyperthermia (MH) is a life-threatening biochemical process of hypermetabolism brought about in susceptible individuals by a triggering drug or event. Type A aortic dissections are surgical emergencies requiring cardiopulmonary bypass and frequently deep hypothermic circulatory arrest. We present a case of suspected MH in a patient undergoing emergent repair of a type A aortic dissection. Upon arrival at our institution, the patient had multiple signs of MH. However, no known triggering agent had been administered. Eventually, the unique physiologic changes of cardiopulmonary bypass provided strong support for the diagnosis of MH and dantrolene was administered, effectively treating the episode.
恶性高热（MH）是一种危及生命的高代谢生化过程，在易感个体中由触发药物或事件引发。A型主动脉夹层是需要体外循环且常需深低温停循环的外科急症。我们报告一例在接受A型主动脉夹层急诊修复的患者中疑似发生恶性高热的病例。该患者到达我院时出现了多种恶性高热的体征。然而，并未给予已知的触发药物。最终，体外循环独特的生理变化为恶性高热的诊断提供了有力支持，随后给予了丹曲林，有效地治疗了这一发作。
