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经开放性胎儿手术成功治疗先天性囊性腺瘤样畸形：1例5年随访的符合医疗规范病例报告及文献复习

Successfully treated congenital cystic adenomatoid malformation by open fetal surgery: A care-compliant case report of a 5-year follow-up and review of the literature.

作者信息

Fan Dazhi, Wu Shuzhen, Wang Rui, Huang Yi, Fu Yao, Ai Wen, Zeng Meng, Guo Xiaoling, Liu Zhengping

机构信息

aFoshan Fetal Treatment Center bDepartment of Obstetrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, Foshan, Guangdong cDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

出版信息

Medicine (Baltimore). 2017 Jan;96(2):e5865. doi: 10.1097/MD.0000000000005865.

DOI:10.1097/MD.0000000000005865
PMID:28079822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5266184/
Abstract

BACKGROUND

Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis.

CASE SUMMARY

A 22-year-old G2P0 woman presented at (Equation is included in full-text article.)weeks' gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at (Equation is included in full-text article.)weeks' gestation. Open fetal surgery was performed to resection the lesion at (Equation is included in full-text article.)weeks' gestation under deep maternal general anesthesia. The mother presented at (Equation is included in full-text article.)weeks after open fetal surgery with preterm premature rupture of membranes (PPROM) and underwent cesarean delivery at (Equation is included in full-text article.)weeks' gestation. A vigorous woman infant of 1955 g, with good Apgar score, was delivered. At 1 month, 4 years, and present, 5 years after birth, she has continued to do well without any obvious deficit and both respiration and circulation were well maintained.

CONCLUSION

We present one case of CCAM which was cured by open fetal surgery and continued to do well at follow-up of 5 years. The success of treatment provided preliminary experience for further carrying out such interventions in China.

摘要

背景

先天性囊性腺瘤样畸形（CCAM）是一种罕见的错构瘤性囊性病变。目前，开放性胎儿手术为诊断为CCAM的胎儿提供了一种潜在的治疗选择。

病例摘要

一名22岁、孕2产0的女性在（具体孕周包含在全文中）孕周时因胎儿左肺病变前来评估，并在（具体孕周包含在全文中）孕周时被诊断为CCAM。在母亲全身深度麻醉下，于（具体孕周包含在全文中）孕周进行开放性胎儿手术切除病变。开放性胎儿手术后（具体孕周包含在全文中）周，母亲出现胎膜早破（PPROM），并在（具体孕周包含在全文中）孕周接受剖宫产。分娩出一名体重1955g、活力良好、阿氏评分高的女婴。出生后1个月、4岁以及目前出生5年后，她一直情况良好，无明显缺陷，呼吸和循环维持良好。

结论

我们报告1例经开放性胎儿手术治愈的CCAM病例，随访5年情况良好。该治疗的成功为在中国进一步开展此类干预提供了初步经验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/80fc6b2cbfab/medi-96-e5865-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/e80b130caa1c/medi-96-e5865-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/d878b938f98a/medi-96-e5865-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/9f9ff98adadd/medi-96-e5865-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/8302821e259b/medi-96-e5865-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/80fc6b2cbfab/medi-96-e5865-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/e80b130caa1c/medi-96-e5865-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/d878b938f98a/medi-96-e5865-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/9f9ff98adadd/medi-96-e5865-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/8302821e259b/medi-96-e5865-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/706c/5266184/80fc6b2cbfab/medi-96-e5865-g015.jpg

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Intrauterine therapy for macrocystic congenital cystic adenomatoid malformation of the lung.宫内治疗肺大囊型先天性囊性腺瘤样畸形
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Anesthesia management for open fetal intrauterine surgery.开放性胎儿宫内手术的麻醉管理
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EXIT-to-resection for fetuses with large lung masses and persistent mediastinal compression near birth.EXIT 手术用于治疗临近出生时伴有大的肺肿块和持续性纵隔压迫的胎儿。
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