Center for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, K1N 6N5, Canada.
Angew Chem Int Ed Engl. 2017 May 22;56(22):6280-6283. doi: 10.1002/anie.201611606. Epub 2017 Jan 12.
We have developed an innovative strategy for the formation of angular carbocycles via a gold(I)-catalyzed dehydro Diels-Alder reaction. This transformation provides rapid access to a variety of complex angular cores in excellent diastereoselectivities and high yields. The usefulness of this Au -catalyzed cycloaddition was further demonstrated by accomplishing a 11-steps total synthesis of (±)-magellanine.
我们开发了一种通过金（I）催化的去氢 Diels-Alder 反应形成角型碳环的创新策略。这种转化提供了快速获得各种复杂角型核心的方法，具有极好的非对映选择性和高收率。通过完成（±）-麦哲伦碱的 11 步全合成，进一步证明了这种 Au 催化的环加成的有用性。
