溴吡斯的明（美斯的明）继发的白细胞破碎性血管炎：首例可能病例报告
Leukocytoclastic Vasculitis Secondary to Pyridostigmine (Mestinon): Report of a Possible First Case.
作者信息
Singh Gunveen, Hodgson Tim, Clarke David E
机构信息
Medical Student in Internal Medicine at the University of Otago School of Medicine in Dunedin, New Zealand.
Pathology Registrar at the University of Otago School of Medicine in Dunedin, New Zealand.
出版信息
Perm J. 2017;21:15-240. doi: 10.7812/TPP/15-240. Epub 2016 Nov 18.
INTRODUCTION
Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis.
CASE PRESENTATION
A 91-year-old man was diagnosed with ocular myasthenia gravis. He was started on pyridostigmine, and 2 weeks later he developed a rash. The rash was biopsied and found to be secondary to leukocytoclastic vasculitis; the pyridostigmine was stopped, loratadine was started, and the rash resolved.
DISCUSSION
Leukocytoclastic vasculitis is commonly caused by a hypersensitivity reaction to medications, or it can be associated with certain medical conditions. We present a brief review of the most common medications and medical conditions known to cause this reaction, but to our knowledge this is the first description of pyridostigmine causing this reaction.
引言
吡啶斯的明是一种常用于治疗重症肌无力的乙酰胆碱酯酶抑制剂。我们描述了一名近期开始服用吡啶斯的明后出现皮疹的患者，并对白细胞破碎性血管炎进行了综述。
病例介绍
一名91岁男性被诊断为眼肌型重症肌无力。他开始服用吡啶斯的明，2周后出现皮疹。对皮疹进行活检，发现是由白细胞破碎性血管炎引起的；停用了吡啶斯的明，开始服用氯雷他定，皮疹消退。
讨论
白细胞破碎性血管炎通常由对药物的过敏反应引起，或者可能与某些疾病有关。我们简要综述了已知会引起这种反应的最常见药物和疾病，但据我们所知，这是关于吡啶斯的明引起这种反应的首次描述。
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